mTOR: a pharmacologic target for autophagy regulation

被引：2394

作者：

Kim, Young Chul

Guan, Kun-Liang ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92037 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2015年 / 125卷 / 01期

关键词：

TUBEROUS SCLEROSIS COMPLEX; TUMOR-SUPPRESSOR COMPLEX; CELL-CYCLE ARREST; AMINO-ACID LEVELS; RAG GTPASES; MAMMALIAN TARGET; BINDING PARTNER; NUTRIENT STRESS; PROTEIN-KINASE; GAP ACTIVITY;

D O I：

10.1172/JCI73939

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

mTOR, a serine/threonine kinase, is a master regulator of cellular metabolism. mTOR regulates cell growth and proliferation in response to a wide range of cues, and its signaling pathway is deregulated in many human diseases. mTOR also plays a crucial role in regulating autophagy. This Review provides an overview of the mTOR signaling pathway, the mechanisms of mTOR in autophagy regulation, and the clinical implications of mTOR inhibitors in disease treatment.

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页码：25 / 32

页数：8

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