Antigen-specific tolerance strategies for the prevention and treatment of autoimmune disease

被引：238

作者：

Miller, Stephen D. ^{[1
]}

Turley, Danielle M. ^{[1
]}

Podojil, Joseph R. ^{[1
]}

机构：

[1] Northwestern Univ, Immunobiol Ctr, Dept Microbiol Immunol & Interdepartmental, Feinberg Sch Med, Chicago, IL 60611 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2007年 / 7卷 / 09期

关键词：

D O I：

10.1038/nri2153

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The development of safe and effective antigen-specific therapies is needed to treat patients with autoimmune diseases. These therapies must allow for the specific tolerization of self-reactive immune cells without altering host immunity to infectious insults. Experimental models and clinical trials for the treatment of autoimmune disease have identified putative mechanisms by which antigen-specific therapies induce tolerance. Although advances have been made in the development of efficient antigen-specific therapies, translating these therapies from bench to bedside has remained difficult. Here, we discuss the recent advances in our understanding of antigen-specific therapies for the treatment of autoimmune diseases.

引用

页码：665 / 677

页数：13

共 122 条

[101] Differential induction of IgE-mediated anaphylaxis after soluble vs. cell-bound tolerogenic peptide therapy of autoimmune encephalomyelitis [J].