Evidence for a bone-kidney axis regulating phosphate homeostasis

被引：89

作者：

Quarles, LD ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2003年 / 112卷 / 05期

关键词：

D O I：

10.1172/JC1200319687

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A novel circulation phosphaturic hormone is postulated to regulate systemic phosphate homeostasis. Two new studies (see the related articles beginning on pages 683 and 785) reveal that the phosphaturic factor FGF-23 is increased in hypophosphatemic subjects with McCune-Albright syndrome and that secreted frizzled-related protein-4 (sFRP-4), a factor produced by tumors derived from subjects with tumor-induced osteomalacia, also has phosphaturic activity. It remains to be established whether FGF-23 and sFRP-4 represent two distinct phosphatonins or are somehow integrated in a novel phosphate-regulating bone-kidney axis.

引用

收藏

页码：642 / 646

页数：5

相关论文

共 36 条

[1] Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities [J].

Beck, L ;

Karaplis, AC ;

Amizuka, N ;

Hewson, AS ;

Ozawa, H ;

Tenenhouse, HS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (09) :5372-5377

[2] Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent [J].

Berndt, T ;

Craig, TA ;

Bowe, AE ;

Vassiliadis, J ;

Reczek, D ;

Finnegan, R ;

De Beur, SMJ ;

Schiavi, SC ;

Kumar, R .

JOURNAL OF CLINICAL INVESTIGATION, 2003, 112 (05) :785-794

[3] FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate [J].

Bowe, AE ;

Finnegan, R ;

de Beur, SMJ ;

Cho, J ;

Levine, MA ;

Kumar, R ;

Schiavi, SC .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 284 (04) :977-981

[4] High bone density due to a mutation in LDL-receptor-related protein 5 [J].

Boyden, LM ;

Mao, JH ;

Belsky, J ;

Mitzner, L ;

Farhi, A ;

Mitnick, MA ;

Wu, DQ ;

Insogna, K ;

Lifton, RP .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (20) :1513-1521

[5] INTERACTIONS BETWEEN VITAMIN-D DEFICIENCY AND PHOSPHORUS DEPLETION IN THE RAT [J].

BRAUTBAR, N ;

WALLING, MW ;

COBURN, JW .

JOURNAL OF CLINICAL INVESTIGATION, 1979, 63 (02) :335-341

[6] Renal phosphate wasting in fibrous dysplasia of bone is part of a generalized renal tubular dysfunction similar to that seen in tumor-induced osteomalacia [J].

Collins, MT ;

Chebli, C ;

Jones, J ;

Kushner, H ;

Consugar, M ;

Rinaldo, P ;

Wientroub, S ;

Bianco, P ;

Robey, PG .

JOURNAL OF BONE AND MINERAL RESEARCH, 2001, 16 (05) :806-813

[7] Tumors associated with oncogenic osteomalacia express genes important in bone and mineral metabolism [J].

De Beur, SMJ ;

Finnegan, RB ;

Vassiliadis, J ;

Cook, B ;

Barberio, D ;

Estes, S ;

Manavalan, P ;

Petroziello, J ;

Madden, SL ;

Cho, JY ;

Kumar, R ;

Levine, MA ;

Schiavi, SC .

JOURNAL OF BONE AND MINERAL RESEARCH, 2002, 17 (06) :1102-1110

[8] A GENE (PEX) WITH HOMOLOGIES TO ENDOPEPTIDASES IS MUTATED IN PATIENTS WITH X-LINKED HYPOPHOSPHATEMIC RICKETS [J].

FRANCIS, F ;

HENNIG, S ;

KORN, B ;

REINHARDT, R ;

DEJONG, P ;

POUSTKA, A ;

LEHRACH, H ;

ROWE, PSN ;

GOULDING, JN ;

SUMMERFIELD, T ;

MOUNTFORD, R ;

READ, AP ;

POPOWSKA, E ;

PRONICKA, E ;

DAVIES, KE ;

ORIORDAN, JLH ;

ECONS, MJ ;

NESBITT, T ;

DREZNER, MK ;

OUDET, C ;

PANNETIER, S ;

HANAUER, A ;

STROM, TM ;

MEINDL, A ;

LORENZ, B ;

CAGNOLI, M ;

MOHNIKE, KL ;

MURKEN, J ;

MEITINGER, T .

NATURE GENETICS, 1995, 11 (02) :130-136

[9] Targeted disruption of the osteoblast/osteocyte factor 45 gene (OF45) results in increased bone formation and bone mass [J].

Gowen, LC ;

Petersen, DN ;

Mansolf, AL ;

Qi, H ;

Stock, JL ;

Tkalcevic, GT ;

Simmons, HA ;

Crawford, DT ;

Chidsey-Frink, KL ;

Ke, HZ ;

McNeish, JD ;

Brown, TA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (03) :1998-2007

[10] Inhibition of MEPE cleavage by Phex [J].

Guo, R ;

Rowe, PSN ;

Liu, SG ;

Simpson, LG ;

Xiao, ZS ;

Quarles, LD .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 297 (01) :38-45

← 1 2 3 4 →