NPM1 mutations are more stable than FLT3 mutations during the course of disease in patients with acute myeloid leukemia

被引：51

作者：

Palmisano, Michela ^{[1
]}

Grafone, Tiziana ^{[1
]}

Ottaviani, Emanuela ^{[1
]}

Testoni, Nicoletta ^{[1
]}

Baccarani, Michele ^{[1
]}

Martinelli, Giovanni ^{[1
]}

机构：

[1] Univ Bologna, S Orsola Malpighi Hosp, Inst Hematol & Med Oncol L & A Seragnoli, Bologna, Italy

来源：

HAEMATOLOGICA | 2007年 / 92卷 / 09期

关键词：

AML; FLT3; mutation; NPM1; minimal residual disease;

D O I：

10.3324/haematol.11202

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

NPM1 mutations have been reported to be the most frequent mutations in acute myeloid leukemia (AML). They are associated with a wide spectrum of morphologic subtypes of AML, normal karyotype and FLT3 mutations. The high frequency of NPM1 mutations might provide a suitable marker for monitoring residual disease of AML.

引用

页码：1268 / 1269

页数：2

共 8 条

[1] Rapid detection of Flt3 mutations in acute myeloid leukemia patients by denaturing HPLC [J].

Bianchini, M ;

Ottaviani, E ;

Grafone, T ;

Giannini, B ;

Soverini, S ;

Terragna, C ;

Amabile, M ;

Piccaluga, PP ;

Malagola, M ;

Rondoni, M ;

Bosi, C ;

Baccarani, M ;

Martinelli, G .

CLINICAL CHEMISTRY, 2003, 49 (10) :1642-1650

[2] Prevalence, clinical profile, and prognosis of NPM mutations in AML with normal karyotype [J].

Boissel, N ;

Renneville, A ;

Biggio, V ;

Philippe, N ;

Thomas, X ;

Cayuela, JM ;

Terre, C ;

Tigaud, I ;

Castaigne, S ;

Raffoux, E ;

De Botton, S ;

Fenaux, P ;

Dombret, H ;

Preudhomme, C .

BLOOD, 2005, 106 (10) :3618-3620

[3] Nucleophosmin mutations in De novo acute myeloid leukemia:: The age-dependent incidences and the stability during disease [J].

Chou, WC ;

Tang, JL ;

Lin, LI ;

Yao, M ;

Tsay, W ;

Chen, CY ;

Wu, SJ ;

Huang, CF ;

Chiou, RJ ;

Tseng, MH ;

Lin, DT ;

Lin, KH ;

Chen, YC ;

Tien, HF .

CANCER RESEARCH, 2006, 66 (06) :3310-3316

[4] Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. [J].

Falini, B ;

Mecucci, C ;

Tiacci, E ;

Alcalay, M ;

Rosati, R ;

Pasqualucci, L ;

La Starza, R ;

Diverio, D ;

Colombo, E ;

Santucci, A ;

Bigerna, B ;

Pacini, R ;

Pucciarini, A ;

Liso, A ;

Vignetti, M ;

Fazi, P ;

Meani, N ;

Pettirossi, V ;

Saglio, G ;

Mandelli, F ;

Lo-Coco, F ;

Pelicci, P ;

Martelli, MF .

NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (03) :254-266

[5] Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype [J].

Schnittger, S ;

Schoch, C ;

Kern, W ;

Mecucci, C ;

Tschulik, C ;

Martelli, MF ;

Haferlach, T ;

Hiddemann, W ;

Falini, B .

BLOOD, 2005, 106 (12) :3733-3739

[6] Heterogeneous patterns of FLT3 ASP835 mutations in relapsed de novo acute myeloid leukemia:: A comparative analysis of 120 paired diagnostic and relapse bone marrow samples [J].

Shih, LY ;

Huang, CF ;

Wu, JH ;

Wang, PN ;

Lin, TL ;

Dunn, P ;

Chou, MC ;

Kuo, MC ;

Tang, CC .

CLINICAL CANCER RESEARCH, 2004, 10 (04) :1326-1332

[7] Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia [J].

Suzuki, T ;

Kiyoi, H ;

Ozeki, K ;

Tomita, A ;

Yamaji, S ;

Suzuki, R ;

Kodera, Y ;

Miyawaki, S ;

Asou, N ;

Kuriyama, K ;

Yagasaki, F ;

Shimazaki, C ;

Akiyama, H ;

Nishimura, M ;

Motoji, T ;

Shinagawa, K ;

Takeshita, A ;

Ueda, R ;

Kinoshita, T ;

Emi, N ;

Naoe, T .

BLOOD, 2005, 106 (08) :2854-2861

[8] Evolution of FLT3-ITD and D835 activating point mutations in relapsing acute myeloid leukemia and response to salvage therapy [J].

Tiesmeier, J ;

Müller-Tidow, C ;

Westermann, A ;

Czwalinna, A ;

Hoffmann, M ;

Krauter, J ;

Heil, G ;

Ganser, A ;

Serve, H ;

Verbeek, W .

LEUKEMIA RESEARCH, 2004, 28 (10) :1069-1074

← 1 →