Modular genes with metazoan-specific domains have increased tissue specificity

被引：19

作者：

Cohen-Gihon, I ^{[1
]}

Lancet, D ^{[1
]}

Yanai, I ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel

来源：

TRENDS IN GENETICS | 2005年 / 21卷 / 04期

关键词：

D O I：

10.1016/j.tig.2005.02.008

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have systematically examined the domain composition across a comprehensive set of tissue-specific, midrange and housekeeping genes as defined by their mode of expression in 52 normal mouse tissues. We show a definite correlation between the number of domains and the degree of tissue specificity. This trend is further supported by a novel analysis involving the time of origin of each domain. Genes containing metazoan-specific domains are more prevalent in signal transduction and cell-communication pathways, and are depleted in primary metabolism. Our analyses suggest that highly modular gene products have been recruited for tissue-specific functions that are required in complex organisms.

引用

页码：210 / 213

页数：4

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