Kinetic resolution of trans-2-acetoxycycloalkan-l-ols by lipase-catalysed enantiomerically selective acylation

被引：17

作者：

Bódai, V

Orovecz, O

Szakács, G

Novák, L

Poppe, L

机构：

[1] Budapest Univ Technol & Econ, Inst Organ Chem, H-1111 Budapest, Hungary

[2] Budapest Univ Technol & Econ, Hungarian Acad Sci, Res Grp Alkaloid Chem, H-1111 Budapest, Hungary

[3] Budapest Univ Technol & Econ, Dept Agr Chem Technol, H-1111 Budapest, Hungary

来源：

TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 17期

基金：

匈牙利科学研究基金会;

关键词：

D O I：

10.1016/S0957-4166(03)00568-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Kinetic resolution of a series of racemic trans-cycloalkane-1.2-diol monoacetates rac-2a-d was performed by enantiomerically selective transesterification with vinyl acetate catalysed by commercial and our own-prepared fungal lipases to yield diacetates (R,R)-3a-d and monoacetates (S,S)-2a-d in high enantiomeric purity. The monoacetates (R,R)-2a-d were also prepared from the racemic diacetates rac-3a-d by lipase-catalysed hydrolysis. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：2605 / 2612

页数：8

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