An oculomotor representation area within the ventral premotor cortex

被引:55
作者
Fujii, N
Mushiake, H
Tanji, J [1 ]
机构
[1] Tohoku Univ, Sch Med, Dept Physiol, Sendai, Miyagi 980, Japan
[2] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA
[3] Japan Sci & Technol Corp JST, Precursory Res Embryon Sci & Technol PRESTO, Tokyo 105, Japan
关键词
D O I
10.1073/pnas.95.20.12034
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
We explored the ventral part of the premotor cortex (PMV) with intracortical microstimulation (ICMS) while monkeys performed a visual fixation task, to see whether the PMV is involved in oculomotor control. ICMS evoked saccades from a small-restricted region in the PMV, without evoking movements in the limbs, neck, or body. We found the saccade-evoking site in the PMV in a total of three hemispheres in two monkeys. Quantitative analysis of the effects of eye position on saccades evoked by microstimulation of the PMV characterized the evoked saccades as goal directed. The nature of the saccades evoked in the PMV contrasted with the fixed vector nature of saccades evoked by ICMS of the frontal eye field. We also found that neurons in this restricted area of the PMV were active while the animals were performing a saccade task that required them to make saccades toward targets without arm movements. These data provide evidence for the presence of an oculomotor specific subregion within the PMV. This subregion and the surrounding skeletomotor-representing regions of the PMV seem to coordinate oculomotor and skeletomotor control in performing goal-directed motor tasks.
引用
收藏
页码:12034 / 12037
页数:4
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