Antitumor agents.: 228.: Five new agarofurans, reissantins A-E, and cytotoxic principles from Reissantia buchananiii

被引：74

作者：

Chang, FR

Hayashi, K

Chen, IH

Liaw, CC

Bastow, KF

Nakanishi, Y

Nozaki, H

Cragg, GA

Wu, YC

Lee, KH

机构：

[1] Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA

[2] NCI, Screening Technol Branch, Dev Therapeut Program, Div Canc Treatment & Diag,NIH, Frederick, MD 21702 USA

[3] Okayama Univ Sci, Fac Sci, Dept Biochem, Okayama 7000005, Japan

[4] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 11期

关键词：

SESQUITERPENE PYRIDINE ALKALOIDS; TRITERPENES; CONSTITUENTS; DATURADIOL; TERPENOIDS; DITERPENES; WILFORDII; STEROIDS;

D O I：

10.1021/np030241v

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Twenty-one compounds, including five new agarofuran sesquiterpenes, reissantins A-E (1-5), were isolated from Reissantia buchananii by means of bioassay-directed fractionation and their structures identified from spectral data. Reissantins A-C are the first reported simple agarofuran sesquiterpenes to contain a 5-carboxy-N-methyl-2-pyridone (CNMP) substituent, which has previously been found only in macroring agarofuran pyridine alkaloids. The major terpenoid components, celastrol (6) and its methyl ester derivative, pristimerin (7), were significantly active against nine cancer cell lines, including A549, MCF-7, HCT-8, KB, KB-VIN, U-87-MG, PC-3, 1A9, and PTX10 cell lines, with ED50 values ranging from 0.076 to 0.34 mug/mL.

引用

页码：1416 / 1420

页数：5

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