Overexpression of connexin 26 in carcinoma of the pancreas

被引：15

作者：

Kyo, Naganori ^{[1
]}

Yamamoto, Hirofumi ^{[1
]}

Takeda, Yutaka ^{[1
]}

Ezumi, Koji ^{[1
]}

Ngan, Chew Yee ^{[1
]}

Terayama, Motokazu ^{[1
]}

Miyakei, Masakazu ^{[1
]}

Takemasai, Ichiro ^{[1
]}

Ikedai, Masataka ^{[1
]}

Doki, Yuichiro ^{[1
]}

Donoi, Keizo ^{[1
]}

Sekimoto, Mitsugu ^{[1
]}

Nojima, Hiroshi ^{[2
]}

Monden, Morito ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Surg Gastroenterol Surg, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Dept Mol Genet, Res Inst Microbial Dis, Suita, Osaka 5650871, Japan

来源：

ONCOLOGY REPORTS | 2008年 / 19卷 / 03期

关键词：

connexin; 26; pancreatic cancer; gastrointestinal cancer;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Contrary to the previously purported role of gap junction (GJ) associated-protein connexin 26 (Cx26) as a tumor suppressor, increased expression of Cx26 has recently been demonstrated in several human malignancies. Surprisingly, this high expression is reportedly related to poor prognosis in squamous cell lung carcinoma and breast cancer. In this study, we examined levels of Cx26 in various human gastrointestinal (GI) carcinomas, with a focus on pancreatic carcinomas, using immunohistochemistry. Many GI carcinomas displayed abundant Cx26 expression, predominantly in the cytoplasm. Cx26 was detected in 5/8 gastric cancers (62.5%), 6/8 squamous cell carcinomas of the esophagus (75.0%), 7/8 pancreatic cancers (87.5%) and 7/8 colon cancer cases (87.5%). However, Cx26 expression was not present in hepatocellular carcinoma (HCC, 0/8). Extensive immunohistochemical examination was performed on pancreatic carcinomas, revealing strong expression of Cx26 protein in 30/43 cases (70%), weak expression in 6/43 (14%) and no expression in 7/43 (16%). The present study demonstrated up-regulated Cx26 expression in a considerable percentage of GI carcinomas, with the exception of HCC. Our findings suggest that Cx26 may be involved in some of the malignant processes of GI cancers, and especially in pancreatic carcinomas.

引用

页码：627 / 631

页数：5

共 28 条

[1]

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[2]

FREQUENT SOMATIC MUTATIONS AND HOMOZYGOUS DELETIONS OF THE P16 (MTS1) GENE IN PANCREATIC ADENOCARCINOMA [J].