The reemergence of Ebola hemorrhagic fever, Democratic Republic of the Congo, 1995

被引:286
作者
Khan, AS
Tshioko, FK
Heymann, DL
Le Guenno, B
Nabeth, P
Kerstiëns, B
Fleerackers, Y
Kilmarx, PH
Rodier, GR
Nkuku, O
Rollin, PE
Sanchez, A
Zaki, SR
Swanepoel, R
Tomori, O
Nichol, ST
Peters, CJ
Muyembe-Tamfum, JJ
Ksiazek, TG
机构
[1] Ctr Dis Control & Prevent, Natl Ctr Infect Dis, Div Viral & Rickettsial Dis, Sepcial Pathogens Branch, Atlanta, GA USA
[2] Ctr Dis Control & Prevent, Natl Ctr Infect Dis, Div Viral & Rickettsial Dis, Infect Dis Pathol Activ, Atlanta, GA USA
[3] Ctr Dis Control & Prevent, Epidemiol Program Off, Atlanta, GA USA
[4] Minist Hlth, Kinshasa, DEM REP CONGO
[5] WHO, CH-1211 Geneva, Switzerland
[6] Inst Pasteur, Paris, France
[7] Epictr, Paris, France
[8] Med Sans Frontieres, Brussels, Belgium
[9] Inst Trop Med, B-2000 Antwerp, Belgium
[10] Dept Hlth, Natl Inst Virol, Special Pathogens Unit, Johannesburg, South Africa
关键词
D O I
10.1086/514306
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In May 1995, an international team characterized and contained an outbreak of Ebola hemorrhagic fever (EHF) in Kikwit, Democratic Republic of the Congo. Active surveillance was instituted using several methods, including house-to-house search, review of hospital and dispensary logs, interview of health care personnel, retrospective contact tracing, and direct follow-up of suspect cases. In the field, a clinical case was defined as fever and hemorrhagic signs, fever plus contact with a case-patient, or fever plus at least 3 of 10 symptoms. A total of 315 cases of EHF, with an 81% case fatality, were identified, excluding 10 clinical cases with negative laboratory results. The earliest documented case-patient had onset on 6 January, and the last case-patient died on 16 July. Eighty cases (25%) occurred among health care workers. Two individuals may have been the source of infection for >50 cases. The outbreak was terminated by the initiation of barrier-nursing techniques, health education efforts, and rapid identification of cases.
引用
收藏
页码:S76 / S86
页数:11
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