Distinct critical cerebellar subregions for components of verbal working memory

被引:48
作者
Cooper, Freya E. [1 ]
Grube, Manon [1 ]
Von Kriegstein, Katharina [2 ]
Kumar, Sukhbinder [1 ]
English, Philip [3 ]
Kelly, Thomas P. [4 ]
Chinnery, Patrick F. [5 ]
Griffiths, Timothy D. [1 ]
机构
[1] Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
[2] Max Planck Inst Human Cognit & Brain Sci, Leipzig, Germany
[3] Newcastle Univ, Dept Neuroradiol, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
[4] Newcastle Univ, Dept Neuropsychol, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
[5] Newcastle Univ, Dept Neurol, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
关键词
SCA-6; Cerebellum; Cognition; MRI; VBM; Neurodegeneration; VOXEL-BASED MORPHOMETRY; SPINOCEREBELLAR ATAXIA; CEREBROCEREBELLAR NETWORK; PREFRONTAL CORTEX; IMPAIRMENT; CHILDREN; DEFICITS; SYSTEM; SENSORIMOTOR; ORGANIZATION;
D O I
10.1016/j.neuropsychologia.2011.11.017
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
010107 [宗教学]; 030301 [社会学]; 070906 [古生物学及地层学(含古人类学)];
摘要
A role for the cerebellum in cognition has been proposed based on studies suggesting a profile of cognitive deficits due to cerebellar stroke. Such studies are limited in the determination of the detailed organisation of cerebellar subregions that are critical for different aspects of cognition. In this study we examined the correlation between cognitive performance and cerebellar integrity in a specific degeneration of the cerebellar cortex: Spinocerebellar Ataxia type 6 (SCA6). The results demonstrate a critical relationship between verbal working memory and grey matter density in superior (bilateral lobules VI and crus I of lobule VII) and inferior (bilateral lobules VIIIa and VIIb, and right lobule IX) parts of the cerebellum. We demonstrate that distinct cerebellar regions subserve different components of the prevalent psychological model for verbal working memory based on a phonological loop. The work confirms the involvement of the cerebellum in verbal working memory and defines specific subsystems for this within the cerebellum. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码:189 / 197
页数:9
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