Corticotropin-releasing factor plays a permissive role in cerebellar long-term depression

被引：100

作者：

Miyata, M

Okada, D

Hashimoto, K

Kano, M

Ito, M

机构：

[1] Inst Phys & Chem Res, RIKEN, Brain Sci Inst, Lab Memory & Learning, Wako, Saitama 3510198, Japan

[2] Inst Phys & Chem Res, RIKEN, Brain Sci Inst, Lab Cellular Neurophysiol, Wako, Saitama 3510198, Japan

[3] Inst Phys & Chem Res, RIKEN, Brain Sci Inst, Lab Cellular Informat Proc, Wako, Saitama 3510198, Japan

[4] Jichi Med Sch, Dept Physiol, Minami Kawachi, Tochigi 32904, Japan

来源：

NEURON | 1999年 / 22卷 / 04期

关键词：

D O I：

10.1016/S0896-6273(00)80735-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study of rat cerebellar slices yielded two lines of evidence indicating that the corticotropin-releasing factor (CRF) found in climbing fibers (CFs) is critical for the induction of long-term depression (LTD) at the parallel fiber (PF) synapses of Purkinje cells (PCs) by their conjunctive activation with either stimulation of CFs or depolarization of PCs, First, LTD induction was effectively blocked by specific CRF receptor antagonists, alpha-helical CRF-(9-41) (alpha-h CRF) and astressin; and second, LTD was no longer observed in CF-deprived cerebella but was restored by CRF replenishment, The data obtained in this study suggest that these effects are mediated by protein kinase C (PKC) and not by Ca2+ signaling or cyclic GMP (cGMP) production.

引用

页码：763 / 775

页数：13

共 91 条

[1] REDUCED HIPPOCAMPAL LONG-TERM POTENTIATION AND CONTEXT-SPECIFIC DEFICIT IN ASSOCIATIVE LEARNING IN MGLUR1 MUTANT MICE [J].