Abnormal regional homogeneity in young adult suicide attempters with no diagnosable psychiatric disorder: A resting state functional magnetic imaging study

被引：77

作者：

Cao, Jun ^{[1
]}

Chen, Jian-mei ^{[1
]}

Kuang, Li ^{[1
]}

Ai, Ming ^{[1
]}

Fang, Wei-dong ^{[2
]}

Gan, Yao ^{[1
]}

Wang, Wo ^{[3
]}

Chen, Xiao-rong ^{[1
]}

Xu, Xiao-ming ^{[1
]}

Wang, Heng-gang ^{[1
]}

Lv, Zhen ^{[1
]}

机构：

[1] Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing 400016, Peoples R China

[2] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing 400016, Peoples R China

[3] Chongqing Med Univ, Univ Town Hosp, Mental Hlth Ctr, Chongqing 401331, Peoples R China

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 2015年 / 231卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Attempted suicide; Impulsive behavior; fMRI; Cerebral cortex; Hippocampus; Cerebellum; POSITRON-EMISSION-TOMOGRAPHY; MAJOR DEPRESSIVE DISORDER; LATE-ONSET DEPRESSION; RESPONSE-INHIBITION; PREFRONTAL CORTEX; CONNECTIVITY PATTERNS; COMPLETED SUICIDE; WHITE-MATTER; BEHAVIOR; FMRI;

D O I：

10.1016/j.pscychresns.2014.10.011

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Many young adults who attempt suicide have no discernible mental illness, suggesting an etiology distinct from other psychiatric disorders. Neurological anomalies associated with a history of suicidal behavior may predict future risk. In the present study, we explored changes in neural circuit organization associated with suicidal behavior by comparing local synchronization of resting state functional magnetic resonance imaging signals in suicide attempters without a psychiatric diagnosis (SA group, 19.84 +/- 1.61 years, n=19) with those in healthy controls (HC group, 20.30 +/- 1.72 years, n=20) using regional homogeneity (ReHo) analysis. The SA group exhibited significantly lower mean ReHo in the left (L) fusiform and supraorbital inferior frontal gyri, L hippocampus, bilateral parahippocampal and middle frontal gyri, right (R) angular gyros, and cerebellar lobules RVIII, RII, and LVI compared with the HC group. Conversely, in the SA group, ReHo was higher in the R supraorbital middle frontal gyrus, R inferior parietal lobe, and L precuncus. The SA group also had significantly higher total Barratt: Impulsiveness Scale scores compared with the HC group. Local functional connectivity is altered in multiple regions of the cerebral cortex, limbic system, and cerebellum of suicidal young adults. Elucidating the functional deficits associated with these ReHo changes may clarify the pathophysiological mechanisms of suicidal behavior and assist in identifying high-risk individuals. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：95 / 102

页数：8

共 66 条

[1]

Multiple anatomical systems embedded within the primate medial temporal lobe: Implications for hippocampal function [J].