TSLP polymorphisms are associated with asthma in a sex-specific fashion

被引：113

作者：

Hunninghake, G. M. ^{[1
,2
,3
]}

Soto-Quiros, M. E. ^{[4
]}

Avila, L. ^{[4
]}

Kim, H. P. ^{[2
,3
]}

Lasky-Su, J. ^{[1
,3
]}

Rafaels, N. ^{[5
]}

Ruczinski, I. ^{[6
]}

Beaty, T. H. ^{[7
]}

Mathias, R. A. ^{[8
]}

Barnes, K. C. ^{[5
]}

Wilk, J. B. ^{[9
,10
]}

O'Connor, G. T. ^{[9
,10
]}

Gauderman, W. James ^{[11
]}

Vora, H. ^{[11
]}

Baurley, J. W. ^{[11
]}

Gilliland, F. ^{[11
]}

Liang, C. ^{[1
]}

Sylvia, J. S. ^{[1
]}

Klanderman, B. J. ^{[1
,3
]}

Sharma, S. S. ^{[1
,2
,3
]}

Himes, B. E. ^{[1
,12
,13
]}

Bossley, C. J. ^{[14
]}

Israel, E. ^{[2
,3
]}

Raby, B. A. ^{[1
,2
,3
,12
]}

Bush, A. ^{[14
]}

Choi, A. M. ^{[2
,3
]}

Weiss, S. T. ^{[1
,3
,12
]}

Celedon, J. C. ^{[1
,2
,3
,12
]}

机构：

[1] Channing Labs, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Dept Med, Div Pulm & Crit Care Med, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Boston, MA USA

[4] Hosp Nacl Ninos Dr Carlos Saenz Herrera, Div Pediat Pulmonol, San Jose, Costa Rica

[5] Johns Hopkins Univ, Dept Med, Div Allergy & Clin Immunol, Baltimore, MD USA

[6] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Biostat, Baltimore, MD USA

[7] Johns Hopkins Univ, Dept Epidemiol, Bloomberg Sch Publ Hlth, Baltimore, MD USA

[8] NHGRI, Genometr Sect, Inherited Dis Res Branch, NIH, Baltimore, MD USA

[9] NHLBI, Framingham Heart Study, Framingham, MA USA

[10] Boston Univ, Sch Med, Boston, MA 02118 USA

[11] Univ So Calif, Dept Prevent Med, Los Angeles, CA 90089 USA

[12] Brigham & Womens Hosp, Dept Med, Ctr Genom Med, Boston, MA 02115 USA

[13] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[14] Royal Brompton Hosp, Imperial Sch Med, Natl Heart & Lung Inst, London SW3 6LY, England

来源：

ALLERGY | 2010年 / 65卷 / 12期

基金：

美国国家卫生研究院;

关键词：

asthma; genetic association; sex-specific; thymic stromal lymphopoietin; TSLP; THYMIC STROMAL LYMPHOPOIETIN; CHILDHOOD ASTHMA; CELLS; INFLAMMATION; EXPRESSION; RESPONSES; SEVERITY; DISEASE; GROWTH; MICE;

D O I：

10.1111/j.1398-9995.2010.02415.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100108 [医学免疫学];

摘要：

Background: Single nucleotide polymorphisms (SNPs) in thymic stromal lymphopoietin (TSLP) have been associated with IgE (in girls) and asthma (in general). We sought to determine whether TSLP SNPs are associated with asthma in a sex-specific fashion. Methods: We conducted regular and sex-stratified analyses of association between SNPs in TSLP and asthma in families of children with asthma in Costa Rica. Significant findings were replicated in whites and African-American participants in the Childhood Asthma Management Program, in African-Americans in the Genomic Research on Asthma in the African Diaspora study, in whites and Hispanics in the Children's Health Study, and in whites in the Framingham Heart Study (FHS). Main Results: Two SNPs in TSLP (rs1837253 and rs2289276) were significantly associated with a reduced risk of asthma in combined analyses of all cohorts (P values of 2 x 10(-5) and 1 x 10(-5), respectively). In a sex-stratified analysis, the T allele of rs1837253 was significantly associated with a reduced risk of asthma in males only (P = 3 x 10(-6)). Alternately, the T allele of rs2289276 was significantly associated with a reduced risk of asthma in females only (P = 2 x 10(-4)). Findings for rs2289276 were consistent in all cohorts except the FHS. Conclusions: TSLP variants are associated with asthma in a sex-specific fashion.

引用

页码：1566 / 1575

页数：10

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