Telomere structure, replication and length maintenance

被引：27

作者：

Muniyappa, K ^{[1
]}

Kironmai, KM ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Biochem, Bangalore 560012, Karnataka, India

来源：

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1998年 / 33卷 / 04期

关键词：

TG(1-3) repeats; subtelomeric elements; G4-quadruplex structures; telomere replication; telomerase RNA; telomere end-binding proteins; telomere position effect; transcriptional silencing; heterochromatin; recombinational repair; aging; cancer;

D O I：

10.1080/10409239891204242

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Telomeres are the termini of linear eukaryotic chromosomes consisting of tandem repeats of DNA and proteins that bind to these repeat sequences. Telomeres ensure the complete replication of chromosome ends, impart protection to ends from nucleolytic degradation, end-to-end fusion, and guide the localization of chromosomes within the nucleus. In addition, a combination of genetic, biochemical, and molecular biological approaches have implicated key roles for telomeres in diverse cellular processes such as regulation of gene expression, cell division, cell senescence, and cancer. This review focuses on recent advances in our understanding of the organization of telomeres, telomere replication, proteins that bind telomeric DNA, and the establishment of telomere length equilibrium.

引用

页码：297 / 336

页数：40

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