A multicentre double blind comparison of hydroxyzine, buspirone and placebo in patients with generalized anxiety disorder

被引:78
作者
Lader, M
Scotto, JC
机构
[1] Inst Psychiat, London SE5 8AF, England
[2] Hop St Marguerite, Psychiat Serv, F-133274 Marseille 9, France
关键词
hydroxyzine; buspirone; generalized anxiety disorder;
D O I
10.1007/s002130050731
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The efficacy of hydroxyzine and buspirone, controlled by placebo, was investigated in a double-blind, parallel group, multicentre study conducted in France and the UK. A total of 244 patients with generalised anxiety disorder in primary care was allocated randomly to treatments with hydroxyzine (12.5 mg morning and mid-day, 25 mg evening), buspirone (5 mg morning and mid-day, 10 mg evening) or placebo (three capsules/day) for 4 weeks, preceded by a 1-week single-blind placebo run-in and followed by 1-week single-blind placebo administration. Rating scales were applied on days -7, 0, 7, 14, 12, 28 and 35. Seventy percent of the patients were female; the average age was 41 +/- 11 years, and the mean Hamilton Anxiety Score at day 0 was 26.5 +/- 4.2. Only 31 of the 244 patients dropped out, but equally in the three groups. Intention-to-treat LOCF analyses on the primary variable showed a significant difference only between hydroxyzine and placebo with respect to improvement on the Hamilton Anxiety Scale (10.75 versus 7.23 points, respectively). Secondary variables such as CGI and self-ratings (HAD scale) showed both hydroxyzine and buspirone to be more efficacious than placebo. Thus, hydroxyzine is a useful treatment for GAD.
引用
收藏
页码:402 / 406
页数:5
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