Apparent diffusion coefficients in oligodendroglial tumors characterized by genotype

被引:55
作者
Jenkinson, Michael D. [1 ,2 ]
Smith, Trevor S. [3 ]
Brodbelt, Andrew R. [2 ]
Joyce, Kathy A. [4 ]
Warnke, Peter C. [5 ]
Walker, Carol [1 ,4 ]
机构
[1] Univ Liverpool, Div Neurosci, Ctr Clin Sci, Liverpool L9 7LJ, Merseyside, England
[2] Walton Ctr Neurol & Neurosurg, Dept Neurosurg, Liverpool, Merseyside, England
[3] Walton Ctr Neurol & Neurosurg, Dept Neuroradiol, Liverpool, Merseyside, England
[4] Clatterbridge Hosp, JK Douglas Labs, Clatterbridge Cancer Res Trust, Wirral, Merseyside, England
[5] Leibniz Inst Neurobiol, Magdeburg, Germany
关键词
oligodendroglioma; oligoastrocytoma; ADC; DWI; genotype; 1p/19q;
D O I
10.1002/jmri.21062
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: To investigate whether oligodendroglial tumors With or without 1p/19q loss differ in their diffusion-weighted imaging characteristics. Oligodendroglial tumors with or without 1p/19q loss differ in their therapeutic responsiveness and prognosis, and recent reports also suggest that these tumors may differ in their magnetic resonance characteristics and blood volume. Materials and Methods: Apparent diffusion coefficients (ADCs) were assessed in three grade II oligodendrogliomas, nine grade II and five, grade III oligoastrocytomas with known 1p/19q status. Regions of interest (ROIs) were placed on ADC maps: 1) around tumor margins to generate pixel histograms; 2) over minimum and maximum tumor ADC; 3) on areas comparable to the highest choline (Cho)/creatine (Cr) ratio determined from chemical shift imaging (CSI): and 4) across tumor margins to measure the ADC transition coefficient (ATC). Results: Tumor ADC was significantly different from normal brain (P < 0.001). ADC in regions of highest Cho/Cr was greater than minimum ADC and did not correlate with the Cho/Cr ratio. ADC-and ATC were not significantly different between oligodendroglial subtypes or grades. Tumors with intact 1p/ 19q had higher maximum (P = 0.021) and histogram ADC (P = 0.015), and greater ATC (P = 0.001) compared to those with 1p/19q loss, which may reflect differences in edema and cellularity. Conclusion: This preliminary study, identified differences in ADC and ATC. between oligodendroglial tumor genotypes that may reflect underlying biology. Confirmation in a larger series is warranted.
引用
收藏
页码:1405 / 1412
页数:8
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