Complete Sequence and Molecular Epidemiology of IncK Epidemic Plasmid Encoding blaCTX-M-14

被引：74

作者：

Cottell, Jennifer L. ^{[5
]}

Webber, Mark A.

Coldham, Nick G. ^{[2
]}

Taylor, Dafydd L.

Cerdeno-Tarraga, Anna M. ^{[3
]}

Hauser, Heidi ^{[4
]}

Thomson, Nicholas R. ^{[4
]}

Woodward, Martin J. ^{[2
]}

Piddock, Laura J. V. ^{[1
]}

机构：

[1] Univ Birmingham, Sch Immun & Infect, Coll Med & Dent Sci, Birmingham B15 2TT, W Midlands, England

[2] Vet Labs Agcy, Surrey, England

[3] European Nucleotide Arch European Bioinformat Ins, Hinxton, S Cambs, England

[4] Wellcome Trust Sanger Inst, Hinxton, S Cambs, England

[5] Univ Birmingham, Antimicrobial Agents Res Grp, Birmingham B15 2TT, W Midlands, England

来源：

EMERGING INFECTIOUS DISEASES | 2011年 / 17卷 / 04期

关键词：

SPECTRUM BETA-LACTAMASES; ESCHERICHIA-COLI; SPREAD; ENTEROBACTERIACEAE; GENES; CTX-M-14;

D O I：

10.3201/eid1704.101009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antimicrobial drug resistance is a global challenge for the 21st century with the emergence of resistant bacterial strains worldwide. Transferable resistance to beta-lactam antimicrobial drugs, mediated by production of extended-spectrum beta-lactamases (ESBLs), is of particular concern. In 2004, an ESBL-carrying IncK plasmid (pCT) was isolated from cattle in the United Kingdom. The sequence was a 93,629-bp plasmid encoding a single antimicrobial drug resistance gene, bla(CTX-M-14). From this information, PCRs identifying novel features of pCT were designed and applied to isolates from several countries, showing that the plasmid has disseminated worldwide in bacteria from humans and animals. Complete DNA sequences can be used as a platform to develop rapid epidemiologic tools to identify and trace the spread of plasmids in clinically relevant pathogens, thus facilitating a better understanding of their distribution and ability to transfer between bacteria of humans and animals.

引用

页码：645 / 652

页数：8

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