Antigen presenting cells treated in vitro by macrophage colony-stimulating factor and autoantigen protect mice from autoimmunity

被引：12

作者：

Guan, Yangtai ^{[1
]}

Yu, Shuo ^{[1
]}

Zhao, Zhao ^{[1
]}

Ciric, Bogojub ^{[1
]}

Zhang, Guang-Xian ^{[1
]}

Rostami, Abdolmohamad ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Dept Neurol, Philadelphia, PA 19107 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2007年 / 192卷 / 1-2期

关键词：

APC; suppression; experimental autoimmune encephalomyelitis;

D O I：

10.1016/j.jneuroim.2007.09.021

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Macrophage colony-stimulating factor (M-CSF) is a critical cytokine in the development of monocytic lineage and may have immunoregulatory properties. Here we show that peritoneal antigen presenting cells (APCs) treated with M-CSF produced decreased levels of proinflammatory cytokines IFN-gamma, TNF-alpha and IL-12. These APCs treated with M-CSF+autoantigen peptide significantly suppressed antigenspecific T cell proliferation, induced regulatory CD4(+), and CD8(+) T cells in vitro and in vivo, and significantly suppressed experimental autoimmune encephalomyelitis (EAE). Thus, in vitro treatment of APCs with M-CSF+autoantigen can be a novel therapeutic option for autoiinmune diseases. (c) 2007 Elsevier B.V All rights reserved.

引用

页码：68 / 78

页数：11

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