Force spectroscopy of the fibrin(ogen) - Fibrinogen interaction

被引：7

作者：

Chtcheglova, Lilia A. ^{[1
]}

Haeberli, Andre ^{[2
]}

Dietler, Giovanni ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Lab Phys Mat Vivante, CH-1015 Lausanne, Switzerland

[2] Univ Bern, Inselspital, Dept Clin Res, CH-3010 Bern, Switzerland

来源：

BIOPOLYMERS | 2008年 / 89卷 / 04期

关键词：

force spectroscopy; atomic force microscope; AFM; fibrinogen; fibrin;

D O I：

10.1002/bip.20910

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Fibrin aggregation is of vital importance in many physiological and pathological processes, such as blood coagulation, wound healing, and thrombosis. In the present study, we investigated the forces involved in the initial steps of the fibrinogen fibrin aggregation by force spectroscopy using the atomic force microscope. Our data confirm the existence of strong specific interactions between fibrin and fibrin (ogen), with unbinding forces ranging from 290 to 375 pN and a logarithmic dependence on the loading rate between 0.8 and 23 nN/s. (c) 2007 Wiley Periodicals, Inc.

引用

页码：292 / 301

页数：10

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