Control of dimensional stability and degradation rate in electrospun composite scaffolds composed of poly(D,L-lactide-co-glycolide) and poly(ε-caprolactone)

被引：32

作者：

Liu, Yi-jie ^{[1
]}

Jiang, Hong-liang ^{[1
]}

Li, Yan ^{[1
]}

Zhu, Kang-jie ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Polymer Sci & Engn, Hangzhou 310027, Peoples R China

来源：

CHINESE JOURNAL OF POLYMER SCIENCE | 2008年 / 26卷 / 01期

关键词：

electrospun; PCL; PLGA; shrinkage; degradation;

D O I：

10.1142/S0256767908002674

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 [高分子化学与物理]; 080501 [材料物理与化学]; 081704 [应用化学];

摘要：

The purpose of this study is to investigate the effect of composition poly(D,L-lactide-co-glycolide)/poly(epsilon-caprolactone) (PLGA/PCL) blending on the morphology, shrinkage and degradation behaviors of the electrospun fibers. With the increase of PLGA content in the composite fibers, the average diameter of the electrospun fibers increased from 1.35 mu m to 1.95 mu m. The serious shrinking of the electrospun PLGA meshes could be circumvented by adding 20% PCL in the fibers, resulting from the semi-crystalline nature of PCL. The degradation rate of the electrospun meshes could be modulated by PLGA/PCL composition. In addition, the electrospun meshes containing 20% PCL displayed stable dimensional morphology with degradation.

引用

页码：63 / 71

页数：9

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