High prevalence of human papillomavirus type 58 in Mexican colposcopy patients

被引:40
作者
González-Losa, MD
Rosado-Lopez, I
Valdez-González, N
Puerto-Solís, M
机构
[1] Dr Hideyo Noguchi Autonomous Univ Yucatan, Reg Res Ctr, Virol Lab, Merida 97000, Yucatan, Mexico
[2] Hlth Minist, OHoran Gen Hosp, Clin Dysplasias, Merida, Yucatan, Mexico
关键词
human papillomavirus; cervical cancer; Mexico; genotype; 58;
D O I
10.1016/S1386-6532(03)00138-0
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Background: Cervical cancer is the second most common cancer of the women worldwide. Infection with some genotypes of human papillomavirus is the most important risk factor associated to cervical cancer. Objective: To determine the prevalence and genotypes of papillomavirus in biopsies of women with squamous intraepithelial lesion and cervical cancer. Study design: Two hundred sequential patients of colposcopy clinic were studied. HPV diagnosis was done by polymerase chain reaction using MY09/MY11 primers, for genotyping line blot hybridization was used. Results: A total of 186 women were p globin positive; 104 (55.9%) had histology diagnosis of low-grade squamous intraepitelial lesions (LSIL), 67 (36.0%) high-grade squamous intraepitelial lesions (HSIL) and 15 (8.1%) invasive cervical cancer (IC). The prevalence of HPV was 56.4% (104/185); HPV 58 was founded in 28.5% of all positive women, HPV 16 in 25.7%, HPV 18 in 13.3%, HPV 33 in 11.4% and 31 in 8.5%. In all grades of the lesions HPV 58 was the most frequently. Conclusions: The high prevalence of HPV 58 among Mexican women with HSIL and IC, has important implications in prophylaxis. (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码:202 / 205
页数:4
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