Matrix metalloproteinases in cerebrovascular diseases

被引:52
作者
Fatar, M [1 ]
Stroick, M [1 ]
Griebe, M [1 ]
Hennerici, M [1 ]
机构
[1] Heidelberg Univ, Klinikum Mannheim, Dept Neurol, DE-68135 Mannheim, Germany
关键词
stroke; carotid artery stenosis; vascular dementia; intracranial haemorrhage; aneurysm; matrix metalloproteinases;
D O I
10.1159/000087197
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Matrix metalloproteinases are important factors for tissue remodelling and are activated during several physiological and pathological conditions, including cerebrovascular diseases. We give an overview of the structure, production and physiological effects of these widely distributed proteases and describe the genetic background and regulation pathways. In particular, we discuss the role of matrix metalloproteinases in vascular remodelling concerning ischaemic stroke, brain haemorrhage, vascular dementia, carotid artery plaques and cerebral aneurysms. Copyright (C) 2005 S. Karger AG, Basel.
引用
收藏
页码:141 / 151
页数:11
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