Release evaluation of drugs from ordered three-dimensional silica structures

被引：192

作者：

Izquierdo-Barba, I ^{[1
]}

Martinez, A ^{[1
]}

Doadrio, AL ^{[1
]}

Pérez-Pariente, J ^{[1
]}

Vallet-Regí, M ^{[1
]}

机构：

[1] Univ Complutense, Dept Quim Inorgan & Bioinorgan, Fac Farm, ES-28040 Madrid, Spain

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2005年 / 26卷 / 05期

关键词：

ordered mesoporous materials; erythromycin; ibuprofen; three-dimensional matrices; cubic structures; functionalization;

D O I：

10.1016/j.ejps.2005.06.009

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cubic mesoporous structures with Ia3d symmetry, such as MCM-48 and large pore Ia3d material (LP-Ia3d), which present different pore size (3.6 and 5.7 nm, respectively), have been prepared, characterized and used as drug delivery systems. Ibuprofen and erythromycin have been chosen as drug models for delivery studies. The influence of the pore size at these structures has been studied and the results show that the delivery rate of drugs decreases with the pore size of the matrix. The influence of chemical nature of the pore surface on the delivery process has been also studied. In this case, the hydrophilic pore surface has been modified with hydrocarbon chains (C8 and C18 moieties) and the effect upon drug delivery of hydrophobic drugs like erythromycin has been studied. The results show a noticeable decrease of the delivery rate when the surface of the matrices is modified. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：365 / 373

页数：9

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