Associative retrieval processes in the human medial temporal lobe: Hippocampal retrieval success and CA1 mismatch detection

被引：96

作者：

Chen, Janice ^{[1
]}

Olsen, Rosanna K. ^{[1
,2
]}

Preston, Alison R. ^{[3
,4
]}

Glover, Gary H. ^{[5
,6
]}

Wagner, Anthony D. ^{[1
,5
]}

机构：

[1] Stanford Univ, Dept Psychol, Stanford, CA 94305 USA

[2] Rotman Res Inst, Toronto, ON M6A 2E1, Canada

[3] Univ Texas Austin, Dept Psychol, Austin, TX 78712 USA

[4] Univ Texas Austin, Ctr Learning & Memory, Austin, TX 78712 USA

[5] Stanford Univ, Neurosci Program, Stanford, CA 94305 USA

[6] Stanford Univ, Dept Radiol, Stanford, CA 94305 USA

来源：

LEARNING & MEMORY | 2011年 / 18卷 / 08期

关键词：

HIGH-RESOLUTION FMRI; COMPLEMENTARY-LEARNING-SYSTEMS; EVENT-RELATED FMRI; RELATIONAL INFORMATION; PATTERN SEPARATION; MEMORY-RETRIEVAL; PHASE PRECESSION; PLACE CELLS; MATCH; RECOGNITION;

D O I：

10.1101/lm.2135211

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Hippocampal subfields CA(3) and CA(1) are hypothesized to differentially support the generation of associative predictions and the detection of associative mismatches, respectively. Using high-resolution functional MRI, we examined hippocampal subfield activation during associative retrieval and during subsequent comparisons of memory to matching or mismatching decision probes. Activity in the dentate gyrus/CA(2/3), CA(1), and other medial temporal lobe subregions tracked associative retrieval success, whereas activity in CA(1) and the perirhinal cortex tracked the presence of associative mismatches. These data support the hypothesis that CA(1) acts as a "comparator," detecting when memory for the past and sensory input in the present diverge.

引用

页码：523 / 528

页数：6

共 49 条

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Pattern separation in the human hippocampal CA3 and dentate gyrus [J].