The therapeutic use of topical contact sensitizers in benign dermatoses

被引:66
作者
Buckley, DA [1 ]
Du Vivier, AWP [1 ]
机构
[1] Kings Coll Hosp London, Dept Dermatol, London SE5 9RS, England
关键词
alopecia areata; contact hypersensitivity; dinitrochlorobenzene; diphencyprone; diphenylcyclopropenone; squaric acid dibutyl ester; topical immunotherapy; viral warts;
D O I
10.1046/j.1365-2133.2001.04399.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Topical therapy using contact sensitizers has been practised since the 1960s to treat conditions associated with an altered immunological state. Dinitrochlorobenzene, squaric acid dibutyl ester and diphencyprone are most commonly employed in the therapy of alopecia areata and viral warts. Few dermatology departments in the U.K. provide such treatment. This systematic review discusses the various contact sensitizers used for topical immunotherapy, the methodology of treatment, factors influencing efficacy and likely adverse effects.
引用
收藏
页码:385 / 405
页数:21
相关论文
共 195 条
[1]   Hazards in the use of diphencyprone [J].
Adisesh, A ;
Beck, M ;
Cherry, NM .
BRITISH JOURNAL OF DERMATOLOGY, 1997, 136 (03) :470-470
[2]   Severe urticarial reaction to diphenylcyclopropenone therapy for alopecia areata [J].
Alam, M ;
Gross, EA ;
Savin, RC .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1999, 40 (01) :110-112
[3]  
Amer M, 1997, J EUR ACAD DERMATOL, V9, P83
[4]   STRUCTURES OF, AND CHARGE SEPARATION IN, "2,3-DIPHENYL-4,4-DICYANOTRIAFULVENE AND 2,3-DIPHENYLCYCLOPROPENONE [J].
AMMON, HL .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1973, 95 (21) :7093-7101
[5]   ALLERGIC AND IRRITANT CONTACT-DERMATITIS COMPARED IN THE TREATMENT OF ALOPECIA TOTALIS AND UNIVERSALIS - A COMPARISON OF THE VALUE OF TOPICAL DIPHENCYPRONE AND TRETINOIN GEL [J].
ASHWORTH, J ;
TUYP, E ;
MACKIE, RM .
BRITISH JOURNAL OF DERMATOLOGY, 1989, 120 (03) :397-401
[6]   INSITU LYMPHOCYTE SUBSETS IN ALOPECIA-AREATA BEFORE AND DURING TREATMENT WITH A CONTACT ALLERGEN [J].
BAADSGAARD, O ;
LINDSKOV, R ;
CLEMMENSEN, OJ .
CLINICAL AND EXPERIMENTAL DERMATOLOGY, 1987, 12 (04) :260-264
[7]  
BARTH JH, 1986, J AM ACAD DERMATOL, V14, P846, DOI 10.1016/S0190-9622(86)80542-4
[8]   SQUARIC ACID DIBUTYL ESTER IN THE TREATMENT OF ALOPECIA-AREATA [J].
BARTH, JH ;
DARLEY, CR ;
GIBSON, JR .
DERMATOLOGICA, 1985, 170 (01) :40-42
[9]   TOPICAL DNCB THERAPY FOR RESISTANT WARTS [J].
BEKHOR, PS ;
ENTWISLE, BR ;
MCKENZIE, IFC .
AUSTRALASIAN JOURNAL OF DERMATOLOGY, 1978, 19 (01) :28-30
[10]  
Benoldi D, 1985, G Ital Dermatol Venereol, V120, P231