Deletion at chromosome band 20p 12.1 in colorectal cancer revealed by high resolution array comparative genomic hybridization

被引：23

作者：

Davison, EJ

Tarpey, PS

Fiegler, H

Tomlinson, IPM

Carter, NP

机构：

[1] Univ Leeds, Mol Med Unit, St Jamess Univ Hosp, Leeds LS9 7TF, W Yorkshire, England

[2] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England

[3] Canc Res UK, Mol & Populat Genet Lab, London WC2A 3PX, England

[4] St Marks Hosp, Canc Res UK, Colorectal Canc Unit, Harrow HA1 3UJ, Middx, England

来源：

GENES CHROMOSOMES & CANCER | 2005年 / 44卷 / 04期

关键词：

D O I：

10.1002/gcc.20252

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Array comparative genomic hybridization (Array CGH) with tiling path resolution for a similar to 4.61 Mb region of chromosome band 20p12.1 has been used to investigate copy number loss in 48 colorectal cancer cell lines and 37 primary colorectal cancers. A recurrent deletion was detected in 55% of cell lines and 23% of primary cancers and the consensus minimum region of loss was identified as a similar to 190kb section from 14.85 Mb to 15.04 Mb of chromosome 20. Two noncoding RNA genes located in the region, BA318C17.1 and DJ974N19.1, were investigated by mutation analysis and real-time PCR in colorectal cancer cell lines. Sequence changes in BA318C17.1 and reduced expression of both genes was detected, suggesting that the abrogation of these genes may play a role in colorectal tumorigenesis. (c) 2005 Wiley-Liss, Inc.

引用

页码：384 / 391

页数：8

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