Discovering pluripotency: 30 years of mouse embryonic stem cells

被引：108

作者：

Evans, Martin ^{[1
]}

机构：

[1] Cardiff Univ, Cardiff CF10 3AT, S Glam, Wales

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2011年 / 12卷 / 10期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

TERATOCARCINOMA CELLS; IN-VITRO; SURFACE-ANTIGENS; CARCINOMA-CELLS; DIFFERENTIATION; GENE; LINE; EXPRESSION; GERMLINE; CHIMERAS;

D O I：

10.1038/nrm3190

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Embryonic stem (ES) cells are pluripotent cells isolated from an early embryo and grown as a cell line in tissue culture. Their discovery came from the conjunction of studies in human pathology, mouse genetics, early mouse embryo development, cell surface immunology and tissue culture. ES cells provided a crucial tool for manipulating mouse embryos to study mouse genetics, development and physiology. They have not only revolutionized experimental mammalian genetics but, with the advent of equivalent human ES cells, have now opened new vistas for regenerative medicine.

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页码：680 / 686

页数：7

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