Hemeoxygenase-2 as an O2 sensor in K+ channel-dependent chemotransduction

被引：38

作者：

Kemp, PJ ^{[1
]}

机构：

[1] Univ Cardiff Wales, Sch Biosci, Cardiff CF10 3US, Wales

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 338卷 / 01期

基金：

英国惠康基金;

关键词：

hypoxia; hemeoxygenase-2; BKCa; potassium channels; oxygen sensing;

D O I：

10.1016/j.bbrc.2005.08.110

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The physiological response of the carotid body is critically dependent upon oxygen-sensing by potassium channels expressed in glomus cells. One such channel is the large conductance, voltage- and calcium-dependent potassium channel, BKCa. Although it is well known that a decrease in oxygen evokes glomus cell depolarization, voltage-gated calcium entry, and transmitter release, the molecular identity of the upstream oxygen sensor has been the subject of some controversy for decades. Recently, we have demonstrated that hemeoxygenase-2 associates tightly with recombinant BKCa and that activity of this enzyme confers oxygen sensitivity to the BKCa channel complex. Similar observations were also made in native channels recorded from carotid body glomus cells, suggesting that hemoxygenase-2 functions as an oxygen sensor of native and recombinant BKCa channels. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：648 / 652

页数：5

共 36 条

[1] Stable expression of the human large-conductance Ca2+-activated K+ channel alpha- and beta-subunits in HEK293 cells [J].

Ahring, PK ;

Strobaek, D ;

Christophersen, P ;

Olesen, SP ;

Johansen, TE .

FEBS LETTERS, 1997, 415 (01) :67-70

[2] Neural roles for heme oxygenase:: Contrasts to nitric oxide synthase [J].

Barañano, DE ;

Snyder, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (20) :10996-11002

[3] An integral role for heme oxygenase-1 and carbon monoxide in maintaining peripheral tolerance by CD4+ CD25+ regulatory T cells [J].

Brusko, TM ;

Wasserfall, CH ;

Agarwal, A ;

Kapturczak, MH ;

Atkinson, MA .

JOURNAL OF IMMUNOLOGY, 2005, 174 (09) :5181-5186

[4] A novel oxygen-sensitive potassium current in rat carotid body type I cells [J].

Buckler, KJ .

JOURNAL OF PHYSIOLOGY-LONDON, 1997, 498 (03) :649-662

[5] RELEASE OF ACETYLCHOLINE FROM CAROTID BODY TISSUES . FURTHER STUDY ON EFFECTS OF ACETLYCHOLINE AND CHOLINERGIC BLOCKING AGENTS ON CHEMOSENSORY DISCHARGE [J].

EYZAGUIRRE, C ;

ZAPATA, P .

JOURNAL OF PHYSIOLOGY-LONDON, 1968, 195 (03) :589-+

[6] EFFECTS OF LOW OXYGEN ON THE RELEASE OF DOPAMINE FROM THE RABBIT CAROTID-BODY INVITRO [J].

FIDONE, S ;

GONZALEZ, C ;

YOSHIZAKI, K .

JOURNAL OF PHYSIOLOGY-LONDON, 1982, 333 (DEC) :93-110

[7] Heme regulates allosteric activation of the Slo1 BK channel [J].

Horrigan, FT ;

Heinemann, SH ;

Hoshi, T .

JOURNAL OF GENERAL PHYSIOLOGY, 2005, 126 (01) :7-21

[8] A DIRECT MECHANISM FOR SENSING LOW-OXYGEN LEVELS BY CENTRAL NEURONS [J].

JIANG, C ;

HADDAD, GG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (15) :7198-7201

[9] Cerebrovascular effects of carbon monoxide [J].

Koehler, RC ;

Traystman, RJ .

ANTIOXIDANTS & REDOX SIGNALING, 2002, 4 (02) :279-290

[10] Hypoxia inhibits human recombinant large conductance, Ca2+-activated K+ (maxi-K) channels by a mechanism which is membrane delimited and Ca2+ sensitive [J].

Lewis, A ;

Peers, C ;

Ashford, MLJ ;

Kemp, PJ .

JOURNAL OF PHYSIOLOGY-LONDON, 2002, 540 (03) :771-780

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