A Mendelian randomization study of the effect of type-2 diabetes on coronary heart disease

被引：113

作者：

Ahmad, Omar S. ^{[1
,2
]}

Morris, John A. ^{[1
,3
]}

Mujammami, Muhammad ^{[1
,2
]}

Forgetta, Vincenzo ^{[1
,2
]}

Leong, Aaron ^{[4
,5
]}

Li, Rui ^{[1
,2
,3
]}

Turgeon, Maxime ^{[6
]}

Greenwood, Celia M. T. ^{[6
]}

Thanassoulis, George ^{[2
,3
]}

Meigs, James B. ^{[4
,5
]}

Sladek, Robert ^{[2
,3
]}

Richards, J. Brent ^{[1
,2
,3
,7
]}

机构：

[1] McGill Univ, Jewish Gen Hosp, Lady Davis Inst Med Res, Ctr Clin Epidemiol, Montreal, PQ H3A 0G4, Canada

[2] McGill Univ, Dept Med, Montreal, PQ H3A 0G4, Canada

[3] McGill Univ, Dept Human Genet, Montreal, PQ H3A 0G4, Canada

[4] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Gen Internal Med, Boston, MA 02115 USA

[5] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

[6] McGill Univ, Dept Oncol Epidemiol Biostat & Occupat Hlth & Hum, Montreal, PQ H3A 0G4, Canada

[7] Kings Coll London, Dept Twin Res & Genet Epidemiol, London SE1 7EH, England

来源：

NATURE COMMUNICATIONS | 2015年 / 6卷

关键词：

MULTIPLE GENETIC-VARIANTS; CARDIOVASCULAR-DISEASE; BLOOD-PRESSURE; INSTRUMENTAL VARIABLES; SUSCEPTIBILITY LOCI; INSULIN-RESISTANCE; ADIPONECTIN LEVELS; COMMON VARIANT; ASSOCIATION; RISK;

D O I：

10.1038/ncomms8060

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

In observational studies, type-2 diabetes (T2D) is associated with an increased risk of coronary heart disease (CHD), yet interventional trials have shown no clear effect of glucose-lowering on CHD. Confounding may have therefore influenced these observational estimates. Here we use Mendelian randomization to obtain unconfounded estimates of the influence of T2D and fasting glucose (FG) on CHD risk. Using multiple genetic variants associated with T2D and FG, we find that risk of T2D increases CHD risk (odds ratio (OR) = 1.11 (1.05-1.17), per unit increase in odds of T2D, P = 8.8 x 10(-5); using data from 34,840/114,981 T2D cases/controls and 63,746/130,681 CHD cases/controls). FG in non-diabetic individuals tends to increase CHD risk (OR = 1.15 (1.00-1.32), per mmol . per l, P = 0.05; 133,010 non-diabetic individuals and 63,746/130,681 CHD cases/controls). These findings provide evidence supporting a causal relationship between T2D and CHD and suggest that long-term trials may be required to discern the effects of T2D therapies on CHD risk .

引用

页数：11

共 58 条

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Analysis of common and coding variants with cardiovascular disease in the diabetes heart study [J].