Maternal serum placental growth factor in second trimester trisomy 21 pregnancies

被引：3

作者：

Cowans, N. J. ^{[1
]}

Kisanga, M. C. ^{[1
]}

Spencer, K. ^{[1
]}

机构：

[1] King George Hosp, Dept Clin Biochem, Prenatal Screening Unit, Goodmayes, Essex, England

来源：

PRENATAL DIAGNOSIS | 2012年 / 32卷 / 02期

关键词：

DOWNS-SYNDROME; FACTOR PIGF; PREDICTION;

D O I：

10.1002/pd.2904

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Objective To investigate the levels of placental growth factor (PlGF) in second trimester maternal serum in trisomy 21 cases and euploid controls - an unclear subject in the published literature. Methods Second trimester maternal serum samples from 17 recent (since 2005) and 74 older trisomy 21 cases and 542 euploid controls were extracted from frozen storage and retrospectively analysed for PlGF using a DELFIA Xpress immunoassay platform. Results were converted to multiples of median (MoM) for comparison. Results The control group had a PlGF MoM of 0.99, the recent trisomy 21 cases had a PlGF MoM of 1.13 and the older cases a PlGF MoM of 1.11; however, the differences between trisomy 21 cases and controls were not significant. Conclusion Although we have found no significant change in the second trimester levels of PlGF in trisomy 21 pregnancies, there remains wide disagreement within the literature on the behaviour of this marker during pregnancies of this syndrome. (C) 2012 John Wiley & Sons, Ltd.

引用

页码：117 / 121

页数：5

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