Structural and regulatory functions of keratins

被引:241
作者
Magin, Thomas M.
Vijayaraj, Preethi
Leube, Rudolf E.
机构
[1] Univ Bonn, Bonner Forum Biomed, Inst Physiol Chem, Div Cell Biochem, D-53115 Bonn, Germany
[2] Johannes Gutenberg Univ Mainz, Dept Anat & Cell Biol, D-55128 Mainz, Germany
关键词
keratin; focal adhesion; cell cycle; apoptosis; carcinogenesis; signaling; 14-3-3; phosphorylation; melanosome; Epidermolysis bullosa simplex;
D O I
10.1016/j.yexcr.2007.03.005
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The diversity of epithelial functions is reflected by the expression of distinct keratin pairs that are responsible to protect epithelial cells against mechanical stress and to act as signaling platforms. The keratin cytoskeleton integrates these functions by forming a supracellular scaffold that connects at desmosomal cell-cell adhesions. Multiple human diseases and murine knockouts in which the integrity of this system is destroyed testify to its importance as a mechanical stabilizer in certain epithelia. Yet, surprisingly little is known about the precise mechanisms responsible for assembly and disease pathology. In addition to these structural aspects of keratin function, experimental evidence accumulating in recent years has led to a much more complex view of the keratin cytoskeleton. Distinct keratins emerge as highly dynamic scaffolds in different Settings and contribute to cell size determination, translation control, proliferation, cell type-specific organelle transport, malignant transformation and various stress responses. All of these properties are controlled by highly complex patterns of phosphorylation and molecular associations. (c) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码:2021 / 2032
页数:12
相关论文
共 134 条
[1]  
Ameen NA, 2001, J CELL SCI, V114, P563
[2]   POLARIZED AND FUNCTIONAL EPITHELIA CAN FORM AFTER THE TARGETED INACTIVATION OF BOTH MOUSE KERATIN-8 ALLELES [J].
BARIBAULT, H ;
OSHIMA, RG .
JOURNAL OF CELL BIOLOGY, 1991, 115 (06) :1675-1684
[3]   A keratin 14 'knockout' mutation in recessive epidermolysis bullosa simplex resulting in less severe disease [J].
Batta, K ;
Rugg, EL ;
Wilson, NJ ;
West, N ;
Goodyear, H ;
Lane, EB ;
Gratian, M ;
Dopping-Hepenstal, P ;
Moss, C ;
Eady, RAJ .
BRITISH JOURNAL OF DERMATOLOGY, 2000, 143 (03) :621-627
[4]   Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells [J].
Beil, M ;
Micoulet, A ;
von Wichert, G ;
Paschke, S ;
Walther, P ;
Omary, MB ;
Van Veldhoven, PP ;
Gern, U ;
Wolff-Hieber, E ;
Eggermann, J ;
Waltenberger, J ;
Adler, G ;
Spatz, J ;
Seufferlein, T .
NATURE CELL BIOLOGY, 2003, 5 (09) :803-811
[5]   Desmosome signaling - Inhibition of p38MAPK prevents pemphigus vulgaris IgG-induced cytoskeleton reorganization [J].
Berkowitz, P ;
Hu, PQ ;
Liu, Z ;
Diaz, LA ;
Enghild, JJ ;
Chua, MP ;
Rubenstein, DS .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (25) :23778-23784
[6]   p38MAPK inhibition prevents disease in pemphigus vulgaris mice [J].
Berkowitz, Paula ;
Hu, Peiqi ;
Warren, Simon ;
Liu, Zhi ;
Diaz, Luis A. ;
Rubenstein, David S. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (34) :12855-12860
[7]   Loss-of-function mutations in the keratin 5 gene lead to Dowling-Degos disease [J].
Betz, RC ;
Planko, L ;
Eigelshoven, S ;
Hanneken, S ;
Pasternack, SM ;
Büssow, H ;
Van den Bogaert, K ;
Wenzel, J ;
Braun-Falco, M ;
Rütten, A ;
Rogers, MA ;
Ruzicka, T ;
Nöthen, MM ;
Magin, TM ;
Kruse, R .
AMERICAN JOURNAL OF HUMAN GENETICS, 2006, 78 (03) :510-519
[8]   Transfection of keratin 18 gene in human breast cancer cells causes induction of adhesion proteins and dramatic regression of malignancy in vitro and in vivo [J].
Bühler, H ;
Schaller, G .
MOLECULAR CANCER RESEARCH, 2005, 3 (07) :365-371
[9]  
Byers HR, 2003, J INVEST DERMATOL, V121, P813
[10]   Keratin-dependent, epithelial resistance to tumor necrosis factor-induced apoptosis [J].
Caulin, C ;
Ware, CF ;
Magin, TM ;
Oshima, RG .
JOURNAL OF CELL BIOLOGY, 2000, 149 (01) :17-22