The arduous road to achieving an immunosuppression-free state in kidney transplant recipients

被引:4
作者
Ansari, M. Javeed
Sayegh, Mohamed H.
机构
[1] Brigham & Womens Hosp, Transplantat Res Ctr, Div Renal, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
[3] Harvard Univ, Sch Med, Warren E Grp, Boston, MA USA
[4] Harvard Univ, Sch Med, John P Merrill Chair Transplantat Med, Boston, MA USA
来源
NATURE CLINICAL PRACTICE NEPHROLOGY | 2007年 / 3卷 / 09期
关键词
D O I
10.1038/ncpneph0568
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Since the first successful transplantations were performed around 50 years ago, the lack of improvement in long-term graft survival and the risks associated with immunosuppressive therapy have made the ability to induce tolerance a burning desire among transplantation immunobiologists. These authors outline the considerable challenges that stand in the way of this goal, and proffer their opinion on which strategies are most likely to succeed.
引用
收藏
页码:464 / 465
页数:2
相关论文
共 20 条
  • [1] Heterologous immunity provides a potent barrier to transplantation tolerance
    Adams, AB
    Williams, MA
    Jones, TR
    Shirasugi, N
    Durham, MM
    Kaech, SM
    Wherry, EJ
    Onami, T
    Lanier, JG
    Kokko, KE
    Pearson, TC
    Ahmed, R
    Larsen, CP
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (12) : 1887 - 1895
  • [2] Outcomes at 3 years of a prospective pilot study of Campath-1H and sirolimus immunosuppression for renal transplantation
    Barth, Rolf N.
    Janus, Christina A.
    Lillesand, Christine A.
    Radke, Nancy A.
    Pirsch, John D.
    Becker, Bryan N.
    Fernandez, Luis A.
    Chin, L. Thomas
    Becker, Yolanda T.
    Odorico, Jon S.
    D'Alessandro, Anthony M.
    Sollinger, Hans W.
    Knechtle, Stuart J.
    [J]. TRANSPLANT INTERNATIONAL, 2006, 19 (11) : 885 - 892
  • [3] Correlation between human leukocyte antigen antibody production and serum creatinine in patients receiving sirolimus monotherapy after Campath-1H induction
    Cai, JC
    Terasaki, PI
    Bloom, DD
    Torrealba, JR
    Friedl, A
    Sollinger, HW
    Knechtle, SJ
    [J]. TRANSPLANTATION, 2004, 78 (06) : 919 - 924
  • [4] Campath 1H allows low-dose cyclosporine monotherapy in 31 cadaveric renal allograft recipients
    Calne, R
    Moffatt, SD
    Friend, PJ
    Jamieson, NV
    Bradley, JA
    Hale, G
    Firth, J
    Bradley, J
    Smith, KGC
    Waldmann, M
    [J]. TRANSPLANTATION, 1999, 68 (10) : 1613 - 1616
  • [5] TLR engagement prevents transplantation tolerance
    Chen, L.
    Wang, T.
    Zhou, P.
    Ma, L.
    Yin, D.
    Shen, J.
    Molinero, L.
    Nozaki, T.
    Phillips, T.
    Uematsu, S.
    Akira, S.
    Wang, C. -R.
    Fairchild, R. L.
    Alegre, M. -L.
    Chong, A.
    [J]. AMERICAN JOURNAL OF TRANSPLANTATION, 2006, 6 (10) : 2282 - 2291
  • [6] Immunosuppressive strategies in transplantation
    Denton, MD
    Magee, CC
    Sayegh, MH
    [J]. LANCET, 1999, 353 (9158) : 1083 - 1091
  • [7] Myeloma responses and tolerance following combined kidney and nonmyeloablative marrow transplantation:: In vivo and in vitro analyses
    Fudaba, Y.
    Spitzer, T. R.
    Shaffer, J.
    Kawai, T.
    Fehr, T.
    Delmonico, F.
    Preffer, F.
    Tolkoff-Rubin, N.
    Dey, B. R.
    Saidman, S. L.
    Kraus, A.
    Bonnefoix, T.
    McAfee, S.
    Power, K.
    Kattleman, K.
    Colvin, R. B.
    Sachs, D. H.
    Cosimi, A. B.
    Sykes, M.
    [J]. AMERICAN JOURNAL OF TRANSPLANTATION, 2006, 6 (09) : 2121 - 2133
  • [8] Results from a human renal allograft tolerance trial evaluating the humanized CD52-specific monoclonal antibody alemtuzumab (Campath-1H)
    Kirk, AD
    Hale, DA
    Mannon, RB
    Kleiner, DE
    Hoffmann, SC
    Kampen, RL
    Cendales, LK
    Tadaki, DK
    Harlan, DM
    Swanson, SJ
    [J]. TRANSPLANTATION, 2003, 76 (01) : 120 - 129
  • [9] Multiparameter immune profiling of operational tolerance in liver transplantation
    Martínez-Llordella, M.
    Puig-Pey, I.
    Orlando, G.
    Ramoni, M.
    Tisone, G.
    Rimola, A.
    Latinne, D.
    Margarit, C.
    Bilbao, I.
    Brouard, S.
    Hernandez-Fuentes, M.
    Soulillou, J. -P.
    Sanchez-Fueyo, A.
    [J]. AMERICAN JOURNAL OF TRANSPLANTATION, 2007, 7 (02) : 309 - 319
  • [10] Clinical trials of transplant tolerance: Slow but steady progress
    Matthews, JB
    Ramos, E
    Bluestone, JA
    [J]. AMERICAN JOURNAL OF TRANSPLANTATION, 2003, 3 (07) : 794 - 803