Organotin complexes with pyrrole-2,5-dicarboxaldehyde bis(acylhydrazones). Synthesis, structure, antimicrobial activity and genotoxicity

被引：75

作者：

Bacchi, A

Bonardi, A

Carcelli, M

Mazza, P

Pelagatti, P

Pelizzi, C

Pelizzi, G

Solinas, C

Zani, F

机构：

[1] Univ Parma, Dipartimento Farmaceut, I-43100 Parma, Italy

[2] Univ Parma, Dipartimento Chim Gen Inorgan Chim Analit Chim Fi, I-43100 Parma, Italy

[3] Univ Sassari, Dipartimento Sci Farmaco, I-07100 Sassari, Italy

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 1998年 / 69卷 / 1-2期

关键词：

organotin complexes; acylhydra zones; antimicrobial activity; genotoxicity; pyrole-2,5 dicarboxaldehyde;

D O I：

10.1016/S0162-0134(97)10027-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mono- and bimetallic organotin complexes with pyrrole-2,5-dicarboxaldehyde bis(2-hydroxybenzoylhydrazone) (H(5)dfps) and pyrrole-2,5-dicarboxaldehyde bis(2-picolinoylhydrazone) (H(3)dfpp) were synthesized and characterized by IR, H-1 and Sn-119 NMR spectroscopy. X-ray analysis of the complex [Sn(H(3)dfpS)(C6H5)(2)].(CH3)(2)SO revealed a pentacoordination around tin through a N,N,O terdentate ligand behaviour of the hydrazone. This complex is the most active compound, exhibiting MIC values of 3 and 12 mu g/ml against Gram positive and Gram negative bacteria, respectively. None of the ligands or complexes produced DNA-damage in the Bacillus subtilis rec-assay or showed mutagenic activity in the Salmonella-microsome test. (C) 1998 Elsevier Science Inc. All rights reserved.

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页码：101 / 112

页数：12

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