Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells

被引：420

作者：

van Beelen, Astrid J.

Zelinkova, Zuzana

Taanman-Kueter, Esther W.

Muller, Fernke J.

Hommes, Daniel W.

Zaat, Sebastian A. J.

Kapsenberg, Martien L.

de Jong, Esther C.

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Cell Biol & Histol, NL-1105 AZ Amsterdam, Netherlands

[2] Univ Amsterdam, Acad Med Ctr, Dept Gastroenterol, NL-1105 AZ Amsterdam, Netherlands

[3] Univ Amsterdam, Acad Med Ctr, Dept Microbiol, Ctr Infect & Immun, NL-1105 AZ Amsterdam, Netherlands

[4] Univ Amsterdam, Acad Med Ctr, Dept Microbiol, Dept Dermatol, NL-1105 AZ Amsterdam, Netherlands

来源：

IMMUNITY | 2007年 / 27卷 / 04期

关键词：

D O I：

10.1016/j.immuni.2007.08.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

How the development of antibacterial T helper 17 (Thl 7) cells is selectively promoted by antigen-presenting dendritic cells (DCs) is unclear. We showed that bacteria, but not viruses, primed human DCs to promote IL-17 production in memory Th cells through the nucleoticle oligomerization domain 2 (NOD2)-ligand muramyldipeptide (MDP), a derivative of bacterial peptidoglycan. MDP enhanced obligate bacterial Toll-like receptor (TLR) agonist induction of IL-23 and IL-1, which promoted IL-1 7 expression in T cells. The role of NOD2 in this IL-23-IL-1 -IL17 axis could be confirmed in NOD2-deficient DCs, such as DCs from selected Crohn's disease patients. Thus, antibacterial Thl 7-mediated immunity in humans is orchestrated by DCs upon sensing bacterial NOD2-ligand MDP.

引用

收藏

页码：660 / 669

页数：10

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