G protein-coupled receptors: novel targets for drug discovery in cancer

被引：576

作者：

Lappano, Rosamaria ^{[1
]}

Maggiolini, Marcello ^{[1
]}

机构：

[1] Univ Calabria, Dept Pharmacobiol, I-87030 Cosenza, Italy

来源：

NATURE REVIEWS DRUG DISCOVERY | 2011年 / 10卷 / 01期

关键词：

NF-KAPPA-B; GROWTH-FACTOR RECEPTOR; LYSOPHOSPHATIDIC ACID RECEPTOR; SARCOMA-ASSOCIATED-HERPESVIRUS; EGFR SIGNAL TRANSACTIVATION; HEDGEHOG PATHWAY INHIBITOR; GASTRIN-RELEASING-PEPTIDE; A(3) ADENOSINE RECEPTOR; BREAST-CANCER; CHEMOKINE RECEPTOR;

D O I：

10.1038/nrd3320

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

G protein-coupled receptors (GPCRs) belong to a superfamily of cell surface signalling proteins that have a pivotal role in many physiological functions and in multiple diseases, including the development of cancer and cancer metastasis. Current drugs that target GPCRs-many of which have excellent therapeutic benefits-are directed towards only a few GPCR members. Therefore, huge efforts are currently underway to develop new GPCR-based drugs, particularly for cancer. We review recent findings that present unexpected opportunities to interfere with major tumorigenic signals by manipulating GPCR-mediated pathways. We also discuss current data regarding novel GPCR targets that may provide promising opportunities for drug discovery in cancer prevention and treatment.

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页码：47 / 60

页数：14

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