Prenylflavonoids: A new class of non-steroidal phytoestrogen (part 2). Estrogenic effects of 8-isopentenylnaringenin on bone metabolism

被引：59

作者：

Miyamoto, M

Matsushita, Y

Kiyokawa, A

Fukuda, C

Iijima, Y

Sugano, M

Akiyama, T

机构：

[1] Sankyo Co Ltd, Exploratory Chem Res Labs, Shinagawa Ku, Tokyo 1408710, Japan

[2] Sankyo Co Ltd, Pharmacol & Mol Biol Res Labs, Shinagawa Ku, Tokyo 140, Japan

来源：

PLANTA MEDICA | 1998年 / 64卷 / 06期

关键词：

prenylflavonoid; isopentenylflavanone; non-steroidal estrogen agonist; phytoestrogen; bone metabolism;

D O I：

10.1055/s-2006-957505

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

In order to examine whether 8-isopentenylnaringenin (1), which has been proven to possess estrogen agonist activity in in vitro tests, also produces in vivo estrogenic properties, the effects of 1 on uterus and on bone metabolism were determined in ovariectomized rats. Rats were ovariectomized and treated with 1 at 30 mg/kg/day subcutaneously for two weeks or 17 beta-estradiol at 0.01 mg/kg/day subcutaneously for two weeks. Ovariectomy resulted in an increase in urinary excretion of bone resorption markers (hydroxyproline, pyridinoline and deoxypyridinoline) and a decrease in bone mineral density of the proximal tibia as well as reduced uterine weight. Treatment with 1 or 17 beta-estradiol completely suppressed these ovariectomy-induced bone and uterine changes in a qualitatively similar manner. These results demonstrate that 1 acts as an estrogen agonist in the uterus as well as in bone in vivo.

引用

页码：516 / 519

页数：4

共 20 条

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[2]

EGGER CD, 1994, J BONE MINER RES, V9, P1211

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