α-synuclein oligomerization:: a role for lipids?

被引：29

作者：

Welch, K ^{[1
]}

Yuan, JY ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

来源：

TRENDS IN NEUROSCIENCES | 2003年 / 26卷 / 10期

关键词：

FATTY-ACID-BINDING; PARKINSONS-DISEASE; SOLUBLE OLIGOMERS; COMMON MECHANISM; MUTATIONS; OCCURS; STABILIZATION; PATHOGENESIS; NITRATION; PROTEINS;

D O I：

10.1016/j.tins.2003.08.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

alpha-Synuclein is a core component of the proteinaceous aggregates observed in several neurodegenerative diseases. A central role of alpha-synuclein in neurodegeneration was demonstrated by the discovery of missense alpha-synuclein mutations in familial Parkinson's disease. However, the specific mechanism by which alpha-synuclein contributes to these diseases remains unclear. A recent study by Sharon et al. linked the presence of specific fatty acids to the appearance of alpha-synuclein oligomers in vivo. alpha-Synuclein oligomers might be a first step in the formation of alpha-synuclein aggregates present in a number of neurodegenerative diseases, although their cytotoxicity remains to be directly demonstrated.

引用

页码：517 / 519

页数：3

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