Effects of serum on in vitro susceptibility testing of echinocandins

被引：62

作者：

Odabasi, Zekaver

Paetznick, Victor

Rex, John H.

Ostrosky-Zeichner, Luis

机构：

[1] Marmara Univ Hosp, TR-34662 Istanbul, Turkey

[2] Univ Texas, Hlth Sci Ctr, Houston, TX USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 11期

关键词：

D O I：

10.1128/AAC.01589-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The effects of protein binding on the activities of caspofungin, anidulafungin, and micafungin were evaluated against Candida and Aspergillus species. Adding human serum sharply increased the MICs of micafungin and anidulafungin and modestly affected the MIC of caspofungin. The increase in MICs does not appear consistent with the rate of protein binding for the three compounds.

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页码：4214 / 4216

页数：3

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