Abnormal cognition and behavior in preterm neonates linked to smaller brain volumes

被引：48

作者：

Bhutta, AT

Anand, KJS

机构：

[1] Univ Arkansas Med Sci, Dept Pediat, Little Rock, AR 72202 USA

[2] Univ Arkansas Med Sci, Arkansas Childrens Hosp, Little Rock, AR 72202 USA

来源：

TRENDS IN NEUROSCIENCES | 2001年 / 24卷 / 03期

关键词：

D O I：

10.1016/S0166-2236(00)01747-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Volumetric measurements of the brain regions in eight-year-old children indicate that the poor cognitive and behavioral outcomes noted in ex-preterm neonates are associated with reduced volumes of specific regions in the brain. Recent literature suggests that this reduction might result from enhanced apoptosis or excitotoxic damage to highly susceptible immature neurons.

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页码：129 / 130

页数：2

相关论文

共 25 条

[1]

Long-term behavioral effects of repetitive pain in neonatal rat pups [J].

Anand, KJS ;

Coskun, V ;

Thrivikraman, KV ;

Nemeroff, CB ;

Plotksy, PM .

PHYSIOLOGY & BEHAVIOR, 1999, 66 (04) :627-637

[2]

The effects of early rearing environment on the development of GABAA and central benzodiazepine receptor levels and novelty-induced fearfulness in the rat [J].

Caldji, C ;

Francis, D ;

Sharma, S ;

Plotsky, PM ;

Meaney, MJ .

NEUROPSYCHOPHARMACOLOGY, 2000, 22 (03) :219-229

[3]

Despres P, 1998, J VIROL, V72, P823

[4]

NATURALLY-OCCURRING CELL-DEATH IN THE CEREBRAL-CORTEX OF THE RAT AND REMOVAL OF DEAD CELLS BY TRANSITORY PHAGOCYTES [J].

FERRER, I ;

BERNET, E ;

SORIANO, E ;

DELRIO, T ;

FONSECA, M .

NEUROSCIENCE, 1990, 39 (02) :451-458

[5]

CALCIUM SIGNALING IN NEURONS - MOLECULAR MECHANISMS AND CELLULAR CONSEQUENCES [J].

GHOSH, A ;

GREENBERG, ME .

SCIENCE, 1995, 268 (5208) :239-247

[6]

Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain [J].

Ikonomidou, C ;

Bosch, F ;

Miksa, M ;

Bittigau, P ;

Vöckler, J ;

Dikranian, K ;

Tenkova, TI ;

Stefovska, V ;

Turski, L ;

Olney, JW .

SCIENCE, 1999, 283 (5398) :70-74

[7]

Inder TE, 1999, ANN NEUROL, V46, P755, DOI 10.1002/1531-8249(199911)46:5<755::AID-ANA11>3.0.CO

[8]

2-0

[9]

Krägeloh-Mann I, 1999, ACTA PAEDIATR, V88, P897

[10]

Liu D, 2000, J NEUROENDOCRINOL, V12, P5