Synthetic polypeptides for biomedical applications

被引：473

作者：

Deming, Timothy J. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

来源：

PROGRESS IN POLYMER SCIENCE | 2007年 / 32卷 / 8-9期

基金：

美国国家科学基金会;

关键词：

polypeptide; N-carboxyanhydride; bioadhesive; antimicrobial; tissue engineering; drug delivery;

D O I：

10.1016/j.progpolymsci.2007.05.010

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

This article summarizes recent developments in the synthesis of copolypeptides from polymerization of alpha-amino acid-N-carboxyanhydrides (NCAs), focusing on their development for potential use in biomedical applications. Block and random copolypeptides of controlled dimensions (including: molecular weight, sequence, composition, and molecular weight distribution) can now be prepared. This review summarizes recent efforts to develop polypeptide hydrogels for tissue engineering applications, polypeptide membranes for therapeutic delivery, polypeptide adhesives for use as surgical sealants, antimicrobial polypeptides for treatment against infectious diseases, and immunomodulating polypeptides for treatment of autoimmune disorders. While these materials show great potential, much development is still required before they will be useful in some of these applications. However, the ability to prepare polypeptides with predictable structure and function puts these applications within reach. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：858 / 875

页数：18

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