Anthraquinone-peptides as inhibitors of AP-1 transcription factor

被引：8

作者：

Ijaz, T ^{[1
]}

Tran, P ^{[1
]}

Ruparelia, KC ^{[1
]}

Teesdale-Spittle, PH ^{[1
]}

Orr, S ^{[1
]}

Patterson, LH ^{[1
]}

机构：

[1] De Montfort Univ, Sch Pharm & Pharmacal Sci, Leicester LE1 9BH, Leics, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 03期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/S0960-894X(00)00653-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Peptide-1-[N-{2-succinamidylethyl}amino]anthraquinones containing five-seven amino acid residues including the KCR motif important in AP-1 protein binding to DNA have been synthesised as potential transcription factor inhibitors. These anthraquinone-peptides showed DNA intercalative binding and inhibition of AP-I protein binding to its DNA consensus sequence. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：351 / 353

页数：3

共 4 条

[1] COMPARATIVE COMPUTER-GRAPHICS AND SOLUTION STUDIES OF THE DNA INTERACTION OF SUBSTITUTED ANTHRAQUINONES BASED ON DOXORUBICIN AND MITOXANTRONE [J].

ISLAM, SA ;

NEIDLE, S ;

GANDECHA, BM ;

PARTRIDGE, M ;

PATTERSON, LH ;

BROWN, JR .

JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (07) :857-864

[2] THE BASIC REGION OF FOS MEDIATES SPECIFIC DNA-BINDING [J].

NAKABEPPU, Y ;

NATHANS, D .

EMBO JOURNAL, 1989, 8 (12) :3833-3841

[3] RESONANCE ENERGY TRANSFER BETWEEN ETHIDIUM BROMIDE MOLECULES BOUND TO NUCLEIC ACIDS - DOES INTERCALATION WIND OR UNWIND DNA HELIX [J].

PAOLETTI, J ;

LEPECQ, JB .

JOURNAL OF MOLECULAR BIOLOGY, 1971, 59 (01) :43-&

[4] MINIMUM LENGTH OF A SEQUENCE-SPECIFIC DNA-BINDING PEPTIDE [J].

TALANIAN, RV ;

MCKNIGHT, CJ ;

RUTKOWSKI, R ;

KIM, PS .

BIOCHEMISTRY, 1992, 31 (30) :6871-6875

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