Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat

被引：207

作者：

Brown, RE ^{[1
]}

Sergeeva, O ^{[1
]}

Eriksson, KS ^{[1
]}

Haas, HL ^{[1
]}

机构：

[1] Univ Dusseldorf, Inst Neurophysiol, D-40001 Dusseldorf, Germany

来源：

NEUROPHARMACOLOGY | 2001年 / 40卷 / 03期

关键词：

hypocretin; narcolepsy; orexin; REM sleep; feeding; 5-HT;

D O I：

10.1016/S0028-3908(00)00178-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Orexin A (10-300 nM) strongly excited dorsal raphe serotonergic neurons maintained in vitro. The depolarization persisted in the presence of tetrodotoxin (TtX, 0.5 muM) and was associated with an increase in input resistance. These results have relevance in the context of food intake regulation and the disease, narcolepsy. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：457 / 459

页数：3

共 9 条

[1]

BROWN RE, 2000, EUROPEAN J NEURO S11, V12, P17

[2] Narcolepsy in orexin knockout mice:: Molecular genetics of sleep regulation [J].

Chemelli, RM ;

Willie, JT ;

Sinton, CM ;

Elmquist, JK ;

Scammell, T ;

Lee, C ;

Richardson, JA ;

Williams, SC ;

Xiong, YM ;

Kisanuki, Y ;

Fitch, TE ;

Nakazato, M ;

Hammer, RE ;

Saper, CB ;

Yanagisawa, M .

CELL, 1999, 98 (04) :437-451

[3] Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems [J].

Date, Y ;

Ueta, Y ;

Yamashita, H ;

Yamaguchi, H ;

Matsukura, S ;

Kangawa, K ;

Sakurai, T ;

Yanagisawa, M ;

Nakazato, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (02) :748-753

[4] From lesions to leptin: Hypothalamic control of food intake and body weight [J].

Elmquist, JK ;

Elias, CF ;

Saper, CB .

NEURON, 1999, 22 (02) :221-232

[5]

JACOBS BL, 1991, PHARMACOL REV, V43, P563

[6] Hypothalamic serotonin in control of eating behavior, meal size, and body weight [J].

Leibowitz, SF ;

Alexander, JT .

BIOLOGICAL PSYCHIATRY, 1998, 44 (09) :851-864

[7] The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene [J].

Lin, L ;

Faraco, J ;

Li, R ;

Kadotani, H ;

Rogers, W ;

Lin, XY ;

Qiu, XH ;

de Jong, PJ ;

Nishino, S ;

Mignot, E .

CELL, 1999, 98 (03) :365-376

[8] Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior [J].

Sakurai, T ;

Amemiya, A ;

Ishii, M ;

Matsuzaki, I ;

Chemelli, RM ;

Tanaka, H ;

Williams, SC ;

Richardson, JA ;

Kozlowski, GP ;

Wilson, S ;

Arch, JRS ;

Buckingham, RE ;

Haynes, AC ;

Carr, SA ;

Annan, RS ;

McNulty, DE ;

Liu, WS ;

Terrett, JA ;

Elshourbagy, NA ;

Bergsma, DJ ;

Yanagisawa, M .

CELL, 1998, 92 (04) :573-585

[9] ELECTROPHYSIOLOGICALAND PHARMACOLOGICAL CHARACTERIZATION OF SEROTONERGIC DORSAL RAPHE NEURONS RECORDED EXTRACELLULARLY AND INTRACELLULARLY IN RAT-BRAIN SLICES [J].

VANDERMAELEN, CP ;

AGHAJANIAN, GK .

BRAIN RESEARCH, 1983, 289 (1-2) :109-119

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