Pneumococcal serotype distribution and antimicrobial resistance in Chinese children hospitalized for pneumonia

被引：83

作者：

Yao, Kai-Hu ^{[1
]}

Wang, Li-Bo ^{[2
]}

Zhao, Gen-Ming ^{[3
]}

Zheng, Yue-Jie ^{[4
]}

Deng, Li ^{[5
]}

Huang, Jing-Fu ^{[6
]}

Wang, Jie-Xiu ^{[7
]}

Zhao, Rui-Zhen ^{[4
]}

Deng, Qiu-Lian ^{[5
]}

Hu, Ying-Hui ^{[8
]}

Yu, Sang-Jie ^{[1
]}

Yang, Yong-Hong ^{[1
]}

Young, Mariano ^{[9
]}

机构：

[1] Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst, Beijing, Peoples R China

[2] Fudan Univ, Pediat Hosp, Shanghai 200433, Peoples R China

[3] Fudan Univ, Sch Publ Hlth, Shanghai 200433, Peoples R China

[4] Shenzhen Childrens Hosp, Shenzhen, Peoples R China

[5] Guangzhou Childrens Hosp, Guangzhou, Guangdong, Peoples R China

[6] Tianjin Childrens Hosp, Tianjin, Peoples R China

[7] Tianjin Dis Prevent & Control Ctr, Tianjin, Peoples R China

[8] Capital Med Univ, Beijing Childrens Hosp, Dept Pulmonol, Beijing, Peoples R China

[9] Wyeth Pharmaceut Inc China, Shanghai, Peoples R China

来源：

VACCINE | 2011年 / 29卷 / 12期

关键词：

Streptococcus pneumoniae; Serotype; Drug resistance; STREPTOCOCCUS-PNEUMONIAE; VACCINE; 19A; IMPACT;

D O I：

10.1016/j.vaccine.2011.01.027

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A prospective study was performed to determine serotype distribution and antimicrobial resistance in Streptococcus pneumoniae (S. pneumoniae) from Chinese children <5 years old meeting pneumonia criteria. A total of 3865 children were enrolled and 338 S. pneumoniae isolates were obtained. The most frequent serotypes were 19F (55.6%), 19A (13.9%), 23F (10.1%), 6B (4.7%), and 14 (3.6%). The 7-, 10- and 13-valent conjugate vaccines, respectively, covered 76.3%, 76.9%, and 92.3% of isolates. Out of the isolates, six (1.8%) were penicillin resistant. All except 1 of the isolates were resistant to erythromycin. Serotype 19A showed the highest drug resistance. The use of PCV7 has the potential to prevent a substantial number of pneumococcal infections. However, PCV13 is likely to prevent more episodes of pneumococcal disease in China because of the high rates of 19A. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：2296 / 2301

页数：6

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