Nonlinear optical contrast enhancement for optical coherence tomography

被引:80
作者
Vinegoni, C [1 ]
Bredfeldt, JS [1 ]
Marks, DL [1 ]
Boppart, SA [1 ]
机构
[1] Univ Illinois, Beckman Inst Adv Sci & Technol, Coll Med,,Dept Bioengn, Dept Elect & Comp Engn, Urbana, IL 61801 USA
来源
OPTICS EXPRESS | 2004年 / 12卷 / 02期
关键词
D O I
10.1364/OPEX.12.000331
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
We present a new interferometric technique for measuring Coherent Anti-Stokes Raman Scattering ( CARS) and Second Harmonic Generation (SHG) signals. Heterodyne detection is employed to increase the sensitivity in both CARS and SHG signal detection, which can also be extended to different coherent processes. The exploitation of the mentioned optical nonlinearities for molecular contrast enhancement in Optical Coherence Tomography (OCT) is presented. (C) 2004 Optical Society of America.
引用
收藏
页码:331 / 341
页数:11
相关论文
共 28 条
[1]  
Bartlett JW, 2002, HIST TODAY, V52, P5
[2]   In vivo cellular optical coherence tomography imaging [J].
Boppart, SA ;
Bouma, BE ;
Pitris, C ;
Southern, JF ;
Brezinski, ME ;
Fujimoto, JG .
NATURE MEDICINE, 1998, 4 (07) :861-865
[3]  
Brown RM, 2003, OPT LETT, V28, P2207, DOI 10.1364/OL.28.002207
[4]   Second-harmonic imaging microscopy for visualizing biomolecular arrays in cells, tissues and organisms [J].
Campagnola, PJ ;
Loew, LM .
NATURE BIOTECHNOLOGY, 2003, 21 (11) :1356-1360
[5]   RELATIVE PHASE MEASUREMENT BETWEEN FUNDAMENTAL AND 2ND-HARMONIC LIGHT [J].
CHANG, RK ;
DUCUING, J ;
BLOEMBERGEN, N .
PHYSICAL REVIEW LETTERS, 1965, 15 (01) :6-+
[6]   Laser-scanning coherent anti-stokes Raman scattering microscopy and applications to cell biology [J].
Cheng, JX ;
Jia, YK ;
Zheng, GF ;
Xie, XS .
BIOPHYSICAL JOURNAL, 2002, 83 (01) :502-509
[7]   Theoretical and experimental characterization of coherent anti-Stokes Raman scattering microscopy [J].
Cheng, JX ;
Volkmer, A ;
Xie, XS .
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS, 2002, 19 (06) :1363-1375
[8]  
DERMTROEDER W, 1998, LASER SPECTROSCOPY
[9]   SCANNING COHERENT ANTI-STOKES RAMAN MICROSCOPE [J].
DUNCAN, MD ;
REINTJES, J ;
MANUCCIA, TJ .
OPTICS LETTERS, 1982, 7 (08) :350-352
[10]   Liquid interfaces probed by second-harmonic and sum-frequency spectroscopy [J].
Eisenthal, KB .
CHEMICAL REVIEWS, 1996, 96 (04) :1343-1360