The total synthesis of eupomatilones 2 and 5

被引：42

作者：

Kabalka, GW ^{[1
]}

Venkataiah, B ^{[1
]}

机构：

[1] Univ Tennessee, Dept Chem, Knoxville, TN 37996 USA

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 43期

关键词：

eupomatilone; indium; organoboron; cross-coupling; Baylis-Hillman;

D O I：

10.1016/j.tetlet.2005.08.140

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Efficient and diastereocontrolled syntheses of natural lignans eupomatilone 2 (1) and 5 (2) are described. Biaryl coupling was achieved using Suzuki chemistry. The lactone moiety was constructed using allylmetal reagents, which were synthesized from Baylis-Hillman adducts. Allylindium reagents were found to be most effective. (c) 2005 Elsevier Ltd. All rights reserved.

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收藏

页码：7325 / 7328

页数：4

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