At issue: Stress, hippocampal neuronal turnover, and neuropsychiatric disorders

被引：29

作者：

Arango, C ^{[1
]}

Kirkpatrick, B ^{[1
]}

Koenig, J ^{[1
]}

机构：

[1] Univ Maryland, Maryland Psychiat Res Ctr, Dept Psychiat, Baltimore, MD 21201 USA

来源：

SCHIZOPHRENIA BULLETIN | 2001年 / 27卷 / 03期

关键词：

schizophrenia; neurodegeneration; neurogenesis; cortisol; stress; hippocampus;

D O I：

10.1093/oxfordjournals.schbul.a006888

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Stress-induced changes in the glucocorticoid system may be toxic for hippocampal cells in animals. Recently, neurogenesis has been shown in the rat, the primate, and the human hippocampus. Because chronic stress is associated with some neuropsychiatric disorders, including schizophrenia, it is possible that an imbalance In the normal turnover of hippocampal cells plays a role in the pathophysiology not only of schizophrenia but also of other neuropsychiatric disorders that involve high levels of stress. New therapeutic possibilities arise if such a process is proven to occur.

引用

页码：477 / 480

页数：4

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