Malignant Glioma: Lessons from Genomics, Mouse Models, and Stem Cells

被引：563

作者：

Chen, Jian ^{[1
]}

Mckay, Renee M. ^{[1
]}

Parada, Luis F. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Dev Biol, Dallas, TX 75390 USA

来源：

CELL | 2012年 / 149卷 / 01期

关键词：

TUMOR-INITIATING CELLS; GROWTH-FACTOR RECEPTOR; SUBVENTRICULAR ZONE; ENDOTHELIAL-CELLS; IDH2; MUTATIONS; DISTINCT CELL; ADULT SVZ; GLIOBLASTOMA; BRAIN; ORIGIN;

D O I：

10.1016/j.cell.2012.03.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Eighty percent of malignant tumors that develop in the central nervous system are malignant gliomas, which are essentially incurable. Here, we discuss how recent sequencing studies are identifying unexpected drivers of gliomagenesis, including mutations in isocitrate dehydrogenase 1 and the NF-kappa B pathway, and how genome-wide analyses are reshaping the classification schemes for tumors and enhancing prognostic value of molecular markers. We discuss the controversies surrounding glioma stem cells and explore how the integration of new molecular data allows for the generation of more informative animal models to advance our knowledge of glioma's origin, progression, and treatment.

引用

页码：36 / 47

页数：12

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