Estrogens in rheumatoid arthritis; the immune system and bone

被引：120

作者：

Islander, Ulrika ^{[1
]}

Jochems, Caroline ^{[1
]}

Lagerquist, Marie K. ^{[1
]}

Forsblad-d'Elia, Helena ^{[1
]}

Carlsten, Hans ^{[1
]}

机构：

[1] Univ Gothenburg, Sahlgrenska Acad, Dept Rheumatol & Inflammat Res, CBAR, S-40530 Gothenburg, Sweden

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2011年 / 335卷 / 01期

关键词：

Rheumatoid arthritis; Estrogen; Selective estrogen receptor modulators; Immune system; bone; COLLAGEN-INDUCED ARTHRITIS; TUMOR-NECROSIS-FACTOR; REGULATORY T-CELLS; KAPPA-B LIGAND; HORMONE-REPLACEMENT THERAPY; OSTEOCLAST DIFFERENTIATION FACTOR; GROWTH-FACTOR-BETA; RANDOMIZED CONTROLLED-TRIAL; BLOOD MONONUCLEAR-CELLS; EXPERIMENTAL POSTMENOPAUSAL POLYARTHRITIS;

D O I：

10.1016/j.mce.2010.05.018

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Rheumatoid arthritis (RA) is an autoimmune disease that is more common in women than in men. The peak incidence in females coincides with menopause when the ovarian production of sex hormones drops markedly. RA is characterized by skeletal manifestations where production of pro-inflammatory mediators, connected to the inflammation in the joint, leads to bone loss. Animal studies have revealed distinct beneficial effects of estrogens on arthritis, and a positive effect of hormone replacement therapy has been reported in women with postmenopausal RA. This review will focus on the influence of female sex hormones in the pathogenesis and progression of RA. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：14 / 29

页数：16

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