Genetic variants in microRNA genes: impact on microRNA expression, function, and disease

被引：118

作者：

Cammaerts, Sophia ^{[1
]}

Strazisar, Mojca ^{[1
]}

De Rijk, Peter ^{[1
]}

Del Favero, Jurgen ^{[1
,2
]}

机构：

[1] Univ Antwerp VIB, Dept Mol Genet, Appl Mol Genom Unit, B-2610 Antwerp, Belgium

[2] Multiplicom NV, Niel, Belgium

来源：

FRONTIERS IN GENETICS | 2015年 / 6卷

关键词：

RNA-BINDING PROTEIN; NUCLEAR EXPORT; PRE-MICRORNA; HUMAN DICER; POSTTRANSCRIPTIONAL REGULATION; WIDE IDENTIFICATION; SECONDARY STRUCTURE; TARGET SITES; HUMAN CANCER; SEED REGION;

D O I：

10.3389/fgene.2015.00186

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学];

摘要：

MicroRNAs (miRNAs) are important regulators of gene expression and like any other gene, their coding sequences are subject to genetic variation. Variants in miRNA genes can have profound effects on miRNA functionality at all levels, including miRNA transcription, maturation, and target specificity, and as such they can also contribute to disease. The impact of variants in miRNA genes is the focus of the present review. To put these effects into context, we first discuss the requirements of miRNA transcripts for maturation. In the last part an overview of available databases and tools and experimental approaches to investigate miRNA variants related to human disease is presented.

引用

页数：12

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